Evolving trends and outcomes in older patients with acute myeloid leukemia including allogeneic stem cell transplantation

A Bazinet, H Kantarjian, N Arani… - American journal of …, 2023 - Wiley Online Library
Outcomes in older patients with acute myeloid leukemia (AML) have historically been poor.
Given advances in low‐intensity therapy (LIT) and stem cell transplantation (SCT), we …

[PDF][PDF] Improving overall survival in older adults with acute myeloid leukemia: subpopulations matter

HE Carraway - J Clin Oncol, 2018 - researchgate.net
The 5-year overall survival (OS) for older (age older than 60 years) adult patients diagnosed
with non-acute promyelocytic leukemia who have acute myeloid leukemia (AML) is only …

Benchmarking treatment effects for patients over 70 with acute myeloid leukemia: A systematic review and meta-analysis

T Reljic, M Sehovic, J Lancet, J Kim, N Al Ali… - Journal of geriatric …, 2020 - Elsevier
Objectives The majority of patients with acute myeloid leukemia (AML) are aged 70 and
over. However, there is uncertainty about how and whether older patients with AML should …

More Versus Less Therapy for Older Adults With Acute Myeloid Leukemia: New Perspectives on an Old Debate.

HD Klepin, E Estey, T Kadia - American Society of Clinical Oncology …, 2019 - europepmc.org
Most patients with newly diagnosed acute myeloid leukemia (AML) are at least age 65 and
continue to have short survival, with many patients receiving no specific anti-AML therapy …

Acute myeloid leukemia in the medically unfit elderly patients

J Edmund, LJ Thaliath, K Meleveedu - Leukemia Research, 2023 - Elsevier
Abstract Acute Myeloid Leukemia is a clonal proliferative disorder whose incidence
increases with age. While studies have shown that the elderly medically unfit patients have …

The demarcation between younger and older acute myeloid leukemia patients: a pooled analysis of 3 prospective studies

M Yanada, S Ohtake, S Miyawaki, H Sakamaki… - Cancer, 2013 - Wiley Online Library
BACKGROUND Contemporary treatment protocols for adult acute myeloid leukemia (AML)
are age‐specific, and older patients are generally treated less intensively than younger …

Outcomes of elderly de novo acute myeloid leukemia treated by a risk‐adapted approach based on age, comorbidity, and performance status

JH Yoon, BS Cho, HJ Kim, JH Kim… - American journal of …, 2013 - Wiley Online Library
Several criteria to define fitness for induction chemotherapy in elderly acute myeloid
leukemia (AML) have been proposed; however, no studies have reported outcomes …

Managing acute myeloid leukemia in the elderly.

M Melchert - Oncology (Williston Park, NY), 2006 - europepmc.org
Acute myeloid leukemia (AML) is a disease of the elderly, with the majority of patients
diagnosed in their 6th and 7th decade of life. Older patients with AML are less likely to …

[HTML][HTML] Acute myeloid leukemia in older adults

M Yanada, T Naoe - International journal of hematology, 2012 - Springer
Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median
age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from …

Changing paradigms in the treatment of acute myeloid leukemia in older patients.

A Bazinet, TM Kadia - Clinical Advances in Hematology & Oncology …, 2022 - europepmc.org
Standard therapy for acute myeloid leukemia (AML) has long consisted of intensive
chemotherapy followed by allogeneic hematopoietic stem cell transplant. Older individuals …