… effects, these compounds also show potential anxiolytic and … The other MT2-selective
agonist, UCM765, also induced a … was found to be as effective as diazepam. The high dose of …

… /anxiolytic combining antagonism of 5HT2C receptors with … In mice, an MT2 receptor agonist
(UCM765) decreased anxiety in … sex differences in the effects of melatonin signalling in the …

… effect in which agomelatine facilitated maturation [37]. Novel MT2 selective partial agonist
UCM765 showed anxiolytic … Comparison of the effects of melatonin and oxazepam on anxiety …

… a prevalent locomotor increase compared to MT2 blockade in … activation of MT2 receptors,
by the partial agonist UCM-765, … striatal melatonin MT2 receptors elicited anxiolytic-like effects. …

… motor performance; however, diazepam reduced the time mice … Microinfusion of MT 2 receptor
partial agonist UCM765 into … in mice, piromelatine exerted anxiolytic activity irrespective of …

… During the extinction training phase, a significantly lower freezing was observed in the
melatonin group in comparison to the vehicle group (group, F (1, 18) = 749.594, p < 0.001; group …

… Membrane-bound melatonin receptors (MT 1 and MT 2 ) … The moderately MT 2 -selective
partial agonist UCM765 has … also reported concerning anxiolytic effects of UCM765 in rats. …

… as an agonist on melatonin MT1 and MT2 receptors. The oral … anxiolytic effects, they may
also exhibit antiepileptic activity [139, 146]. UCM765 is another new agent that acts as an MT2 …

… as a melatonin (MT 1 /MT 2 ) receptor agonist and 5-HT 2C … ) has been reported to mimic the
anxiolytic properties of MT, … -mentioned MT 2 receptor agonist UCM765 activates neurons in …

… UCM765 (39) is a selective MT 2 partial agonist which has been reported to promote non-rapid
eye movement sleep maintenance (40) and has anxiolytic (… We hypothesize that UCM765 …