… randomized clinical trials were identified by a systematic … of care for NTE NDMM patients
are bortezomib-melphalan-… There are currently two systematic literature reviews (SLRs) and …

… The keywords utilized were “multiple myeloma OR … diagnosed OR previously untreated”,
“older patients OR elderly patients OR … with bortezomib plus thalidomide (VMPT-VT) in one trial, …

… proven to be effective in randomized clinical trials (RCTs), … For example, a mixed treatment
comparison meta-analysis in … the treatment settings from previously untreated MM to relapsed/…

(Bortezomib plus lenalidomide/thalidomide)- vs (bortezomib or lenalidomide/thalidomide)-containing
regimens as induction therapy in newly diagnosed multiple myeloma: a meta-…

… 3, randomized controlled trial (RCT)—found no significant difference in progression-free
survival (PFS) between previously-untreated patients … (KRd) versus bortezomib/lenalidomide/…

… To investigate the effect of novel agents like bortezomib, … ) for previously untreated patients
with multiple myeloma, we performed a meta-analysis of randomized controlled trials (RCTs). …

… randomized controlled trials to provide high-quality evidence. … Bortezomib, a reversible
inhibitor of the 26S proteasome, was developed with the aim of treating multiple myeloma (MM) …

… , and from other published systematic reviews and practice … been used in previously
untreated myeloma. Our analysis … of this meta-analysis indicate that the addition of bortezomib to …

… a systematic review and Bayesian network meta-analysis of 29 randomized clinical trials,
enrolling 14,533 patients… OS analysis showed superiority of lenalidomide(R) and bortezomib(V) …

… the Phase III clinical trial APEX, in which single-agent bortezomib demonstrated superior
efficacy to … multiple myeloma: a meta-analysis of randomized controlled trials. Ann. Hematol.91…