… of B7-H4 with existing biomarkers TMB on immunotherapeutic responsiveness. By integrating
B7-H4 stratification with TMB, we identified B7-H4 … to ICIs, while the B7-H4 low TMB low …

… Although recent advances in immunotherapy targeting the B7-CD28 family members PD-L1,
PD… In addition, rs10923223 and rs12046117 displayed protective effects on JIA process, but …

… functional nuclear localization sequence (NLS) where mutation of the NLS abrogated the
nuclear effects of B7-H4, deeming the NLS necessary to promote G 1 /S transition, decrease …

… B7-H4 may alter anti-tumor T-cell immunity with little B7-H4 in tumors in the 4T1 model,
B7-H4-mediated immunotherapies … the advantage of targeting B7-H4 may be twofold as B7-H4 is …

… tissues makes B7-H4 an attractive immunotherapeutic target. Preclinical investigation into …
the inhibitory effects of B7-H4 (2). This suggests that the suppressive effects of B7-H4 may be …

… Furthermore, a survival benefit for patients with B7-H4 low expressing melanoma was found…
B7-H3 and B7-H4 expression in primary and metastatic melanoma lesions. Tumor B7-H4 …

… be just blocking antibodies but have other effects such as triggering the B7-H3 signal. Until
… of B7-H3 and/or B7-H4 represents a realistic opportunity to design new immunotherapeutic …

… B7-H4 in the cancer cells. By using MPE model, we sought to a potential immunotherapy for
MPE with anti-B7-H4 … Taking advantage of an orthotopic model that faithfully mimics human …

… who will and those who will not benefit from immunotherapy has been repeatedly stressed.
Our … reporting a potential role of B7-H4 expression as predictor of benefit from PD-1 blockade …

… expression of B7-H4. Our results also suggest that B7-H4 blockade might benefit gastric cancer
… at advanced stages, as well as some early stage patients with higher B7-H4 expression. …