… that B7-H4 expression is related to an immune-excluded TME and is an independent poor
prognostic factor in ACC. Notably, our preclinical findings support B7-H4 … with B7-H4 targeting …

… and the impact of those panels for immuno-profiling tumor tissues, we … Interestingly, high
density of MCs expressing B7-H4 was … Two different cellular patterns of spatial distribution were …

… to visualize the spatial arrangement and … the immunoprofiling studies, we hypothesized
that inhibitors targeting PD-L1/PD-1 signaling or T reg could augment the antitumor effects of B7-…

… regulation mechanisms of B7-H4 in vitro. We … B7-H4. We assessed therapy response and
transcriptional changes at baseline and under treatment with anti-PD-L1. We observed B7-H4 …

… In conclusion, this study describes the spatial heterogeneity of the immune microenvironment
in NPC and highlights immune-related biomarkers in immune phenotypes, which may aid …

… The development of multiplexed antibody-based (MAB) spatial tissue imaging technologies
… and subtypes, and analysis of the spatial relationships and interactions between them. Such …

… This technology provides spatial analysis and quantification of phenotypes in situ in a
single slide. Vectra Polaris can achieve spatial resolution at level as low as 0.25 μm, making …

… Spatially guided proteomics and histology-guided spatial metabolomics of NSCLC
allowed for the differentiation of two NSCLC subtypes: adenocarcinoma and squamous cell …

… Programmed- death ligand 1 (PD- L1), B7 homolog 3 (B7- H3), and B7 homolog 4 (B7- H4)
were evaluated in all cells and were scored by an H- score, calculated as the percentage of …

… After running a mIHC analysis in HALO, the pathologist then has the option to generate
spatial information using the spatial analysis module. As outlined above, spatial information is …