… chromosome loss … chromosome loss, and we demonstrate that this approach successfully
identifies genes implicated in cell cycle regulation, genome instability and cancer susceptibility…

… these studies of the existence of cancer susceptibility genes that may act in … cancers, we
performed a genomewide-scan linkage study in families selected for aggregation of lung cancer. …

… cell-cycle regulation and cancer susceptibility, as well as somatic drivers of tumour growth
and targets of cancer therapy. We demonstrate that genetic susceptibility to LOY is associated …

… and increased cancer susceptibility, often leading to childhood cancers.9 The patients exhibit
… In addition, 18 of the 20 tissues that we examined showed a bias toward chromosome loss. …

… cancers the Ptprj homologue PTPRJ on chromosome 11p is involved in a specific pathway
of colon-tumour progression that involves the loss of … by the loss of 18q12–21. Therefore, this …

… Y chromosome loss was significantly higher than expected percent seen in lymphocytes, …
loss of the Y chromosome in epithelial cells is a predictive biomarker for prostate cancer in …

… -susceptibility locus to chromosome 1p36. Because an excess of cases of primary brain cancer
(… a high risk for PC, and because loss of heterozygosity at 1p36 is frequently observed in …

… Chromosomal losses involving the short arm of chromosome 8 are frequent in a variety of …
breast cancer susceptibility locus (BRCA3) mapping to the short arm of human chromosome 8. …

… Potential models for explaining the observed associations of mosaic loss of Y chromosome
(LOY) in leukocytes and disease susceptibility. a The “immunosurveillance” hypothesis of …

… chromosomal changes in non-small cell lung carcinomas. Thus, the data on lymphocytic
chromosomal rearrangements in lung cancer … in the etiology of lung cancer but also emphasizes …