Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank

E Loftfield, W Zhou, BI Graubard, M Yeager… - Scientific Reports, 2018 - nature.com
… the shape of the association between mLOY and mortality, we … nonlinear association between
mLOY and mortality risk, we … a Y chromosome gain event since only 11 deaths occurred …

Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men

LA Forsberg - Human genetics, 2017 - Springer
… the Y chromosome in the peripheral blood is associated with increased risk for all-cause
mortality … risk for pathology and mortality associated with mosaic loss of chromosome Y (LOY) in …

[HTML][HTML] Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years

DM Hozakowska-Roszkowska, J Mengel-From… - Mechanisms of Ageing …, 2024 - Elsevier
… previous findings of an association between mLOY and mortality across all study participants
and in men younger than 80 years. Interestingly, we find that this association is inversed in …

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

LA Forsberg, C Rasi, N Malmqvist, H Davies… - Nature …, 2014 - nature.com
… Incidence and mortality for sex-unspecific cancers are higher … Furthermore, age-related
loss of chromosome Y (LOY) is … blood was associated with risks of all-cause mortality (hazards …

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality

…, J Sundström, Y Yura, A Kour, Y Arai, MC Thel, Y Arai… - Science, 2022 - science.org
… Cardiac macrophages lacking the Y chromosome exhibited polarization toward a … is
associated with an increased risk for cardiovascular disease and heart failure–associated mortality. …

Mosaic loss of chromosome Y in blood is associated with Alzheimer disease

JP Dumanski, JC Lambert, C Rasi, V Giedraitis… - The American Journal of …, 2016 - cell.com
… Our previous results show that a fundamentally different genetic variant, ie, lifetime-acquired
loss of chromosome Y (LOY) in blood cells, is associated with all-cause mortality and an …

Mosaic loss of chromosome Y in leukocytes matters

LA Forsberg, J Halvardson, E Rychlicka-Buniowska… - Nature Genetics, 2019 - nature.com
… On the contrary, all our published positive results of associations between LOY and all-cause
mortality, cancer and smoking as well as Alzheimer’s disease have been based on …

[HTML][HTML] Association of mosaic loss of chromosome Y with lung cancer risk and prognosis in a Chinese population

N Qin, N Li, C Wang, Z Pu, Z Ma, G Jin, M Zhu… - Journal of Thoracic …, 2019 - Elsevier
Introduction Mosaic loss of chromosome Y (mLOY) is the most commonly detectable mosaic
chromosomal event in cancers; however, its underlying relationship with tumorigenesis is …

Genetic predisposition to mosaic Y chromosome loss in blood

, … Association Group to Investigate Cancer Associated … - Nature, 2019 - nature.com
… of a Y chromosome provides a selective growth advantage in these cells; we hypothesize
that this could be due to the loss of a putative Y-linked cell-growth suppressor gene; loss of a Y-…

Y Chromosome Loss and Implications for Oncology

CD Dirican, PS Nelson - Molecular Cancer Research, 2024 - AACR
Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and
mortality … Genetic association of mosaic loss of chromosome Y with prostate cancer in men …