… disorders such as Alzheimer disease (AD), chronic traumatic encephalopathy (CTE…
neurodegenerative diseases. This review encompasses acute effects and chronic …

… development of neurodegenerative disease. … brain injury (TBI), including repetitive concussive
and subconcussive trauma, can provoke another distinctive neurodegeneration: chronic …

… Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known …

… brain injuries (eg, ischemia) and chronic neurodegenerative diseases (Alzheimer’s disease,
Parkinson’s disease, tauopathies, and Huntington’s disease). Consistent with this novel …

… brain injury (TBI) is associated with an increased incidence of neurological disease and
psychiatric comorbidities, including chronic … lifetime risk of neurodegeneration. Key factors that …

… atrophy, precipitate or accelerate age-related neurodegeneration, and increase the risk of …
a tauopathy, chronic traumatic encephalopathy. We found early changes of chronic traumatic …

… Acute neuropathologies and chronic neurodegeneration (A) Healthy, myelinated axon prior
to traumatic brain injury (TBI). The box shows detail of the mid-segment of axon with central …

… risk for the development of chronic neurodegenerative diseases, notably chronic traumatic …
neurodegenerative diseases can exacerbate the severity and prognosis of acute brain injuries…

… Elucidating the long-term changes of microglial physiology after TBI will facilitate our
understanding of pathological links between TBI and chronic neurodegenerative disease. …

… In an attempt to test the hypothesis that the microglial response to head injury may persist
and provoke chronic neurodegeneration, we have characterized in detail the time-course and …