Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

P Tomassen, G Vandeplas, T Van Zele… - Journal of Allergy and …, 2016 - Elsevier
… a neutrophilic type of inflammation with involvement of other T-… Therefore we sought to identify
inflammatory endotypes of … Secondarily, we aimed to match these endotypes with clinical …

Phenotypes and emerging endotypes of chronic rhinosinusitis

C Bachert, CA Akdis - The Journal of Allergy and Clinical Immunology: In …, 2016 - Elsevier
… , we refer to inflammatory endotypes that are characterized by a coherent group of cytokines
and T effector cells: Th1, Th2, Th17, Th22, etc. We call those “inflammatory endotypes,” 5 …

Associations between inflammatory endotypes and clinical presentations in chronic rhinosinusitis

WW Stevens, AT Peters, BK Tan, AI Klingler… - The Journal of Allergy …, 2019 - Elsevier
… the known association of T2 inflammation with nasal polyps (NPs) … inflammatory endotypes
are associated with specific clinical presentations. We therefore set out to define the endotype

Use of endotypes, phenotypes, and inflammatory markers to guide treatment decisions in chronic rhinosinusitis

AG Staudacher, AT Peters, A Kato… - Annals of Allergy, Asthma & …, 2020 - Elsevier
… Geographic diversity of inflammatory endotypes in chronic rhinosinusitis (CRS). There is
a marked global heterogeneity in inflammatory endotypes among patients with CRS without …

Endotypes of chronic rhinosinusitis: impact on management

LO Cardell, P Stjärne, K Jonstam, C Bachert - Journal of Allergy and …, 2020 - Elsevier
… by type 2 inflammation; the type 2–high endotype can have … by some degree of eosinophilic
airway inflammation. Aspirin-… counts are biomarkers for type 2 endotype bronchial asthma, …

Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors

X Wang, Y Sima, Y Zhao, N Zhang, M Zheng… - Journal of Allergy and …, 2023 - Elsevier
endotypes of patients with CRS according to inflammatoryinflammatory endotypes and
remodeling factors in CRS. … the existing CRS endotypes on the basis of inflammatory and …

[HTML][HTML] Inflammatory endotypes and microbial associations in chronic rhinosinusitis

M Hoggard, S Waldvogel-Thurlow, M Zoing… - Frontiers in …, 2018 - frontiersin.org
… of inflammation and clinical severity. This study contributes to ongoing efforts to define distinct
endotypes of CRS on the basis of underlying inflammatory … dysbiosis and inflammation in …

Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps

AI Klingler, WW Stevens, BK Tan, AT Peters… - Journal of Allergy and …, 2021 - Elsevier
inflammation in nonpolypoid disease. We further found that the distinct inflammatory endotypes
… it has become clearer that the most frequent inflammatory endotype in CRSsNP is T2, as …

[HTML][HTML] Emerging endotypes of chronic rhinosinusitis and its application to precision medicine

DW Kim, SH Cho - Allergy, asthma & immunology research, 2017 - synapse.koreamed.org
… induce various inflammatory mediators from inflammatory cells, … These inflammatory
mediators are novel potential therapeutic … publications regarding endotypes and endotype-based …

Endotypes of chronic rhinosinusitis: relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches

A Kato, AT Peters, WW Stevens, RP Schleimer… - Allergy, 2022 - Wiley Online Library
… Using ethmoid sinus mucosa and microarray analysis, we recently identified gene
expression profiles in three inflammatory endotypes; T1sNP, T2sNP, and T3sNP, and predicted …