Chronic rhinosinusitis endotyping: Sharpening the focus on inflammation

DL Hamilos - Journal of Allergy and Clinical Immunology, 2016 - jacionline.org
Inflammatory endotypes of chronic rhinosinusitisinflammatory endotype “clusters” and
used a number of validation steps to confirm the optimal number of CRS clusters. The endotypes

Personalized medicine in chronic rhinosinusitis: phenotypes, endotypes, and biomarkers

AM Bauer, JH Turner - Immunology and Allergy Clinics, 2020 - immunology.theclinics.com
Inflammatory endotyping has only recently been explored for CRS, but early studies have
shown consistent findings and advanced understanding of the disease process. …

Highlights in the advances of chronic rhinosinusitis

X Xu, S Reitsma, DY Wang, WJ Fokkens - Allergy, 2021 - Wiley Online Library
Chronic rhinosinusitis (CRS) is a protracted inflammatory … based on visual analogue scale
for rhinosinusitis. This subgroup has … the evolution towards a particular inflammatory endotype. …

Advances in the knowledge of the underlying airway remodeling mechanisms in chronic rhinosinusitis based on the endotypes: a review

K Lee, J Tai, SH Lee, TH Kim - International journal of molecular sciences, 2021 - mdpi.com
Chronic rhinosinusitis (CRS) is a chronic inflammatory condition of the nasal and
paranasal sinus mucosa that affects up to 10% of the population worldwide. CRS is the most …

Phenotypes of chronic rhinosinusitis

SH Cho, DL Hamilos, DH Han, TM Laidlaw - The Journal of Allergy and …, 2020 - Elsevier
… and endotypes. Recent advances in our understanding of the pathogenetic mechanisms of
CRS endotypes … to define CRS “endotypes” on the basis of patterns of inflammatory cell and …

Clinically relevant phenotypes in chronic rhinosinusitis

JW Grayson, M Cavada… - Journal of Otolaryngology …, 2019 - journals.sagepub.com
… as phenotypes and endotypes are being described. There … inflammatory process. Research
continues to shed more light on different endotypes and phenotypes of airway inflammation, …

A review of classification schemes for chronic rhinosinusitis with nasal polyposis endotypes

SK Dennis, K Lam, A Luong - Laryngoscope investigative …, 2016 - Wiley Online Library
… type 2 inflammatory cascades for patients with chronic rhinosinusitis. The typical chronic
rhinosinusitis patients in North America and Europe follow a type 2 inflammatory response with …

An integrated analysis of inflammatory endotypes and clinical characteristics in chronic rhinosinusitis with nasal polyps

D Hao, Y Wu, P Li, C Li, T Jiang, Q Zhang… - … of inflammation …, 2022 - Taylor & Francis
… Furthermore, the associations between T1, T3 or mixed endotypesinflammatory endotypes
are associated with specific clinical characteristics. Improved understandings of endotype-…

Identification of clinically relevant chronic rhinosinusitis endotypes using cluster analysis of mucus cytokines

JH Turner, RK Chandra, P Li, K Bonnet… - Journal of Allergy and …, 2018 - jacionline.org
… Collectively, the inflammatory endotypes outlined in this study confirm that CRS is a
heterogeneous inflammatory disease, and suggest that endotypes likely do not adhere to strict T-…

Endotyping chronic rhinosinusitis with nasal polyps: understanding inflammation beyond phenotypes

CC Chen, KM Buchheit - American Journal of Rhinology & …, 2023 - journals.sagepub.com
… Overall classification of inflammatory endotypes that have been identified in chronic
rhinosinusitis … In this review, we will focus on the current knowledge of inflammatory endotypes in …