Use of endotypes, phenotypes, and inflammatory markers to guide treatment decisions in chronic rhinosinusitis

AG Staudacher, AT Peters, A Kato… - Annals of Allergy, Asthma & …, 2020 - Elsevier
… With the advent of new treatment options for Chronic Rhinosinusitis (CRS) comes the ability
for physicians to provide more individualized patient care. Physicians are now tasked with …

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

P Tomassen, G Vandeplas, T Van Zele… - Journal of Allergy and …, 2016 - Elsevier
… We sought to identify inflammatory endotypes of CRS. Therefore we aimed to cluster patients
with CRS based solely on immune markers in a phenotype-free approach. Secondarily, we …

Chronic rhinosinusitis with nasal polyps: age and disease severity differences in the levels of inflammatory markers

J Vaitkus, A Vitkauskienė, R Simuntis, Ž Vaitkus… - Medicina, 2021 - mdpi.com
… of inflammatory markers in the nasal tissue of patients with chronic rhinosinusitis with nasal
… well as to find associations between age, inflammation development, and NPs. Materials and …

Association of chronic rhinosinusitis with nasal polyps and asthma: clinical and radiological features, allergy and inflammation markers

J Staikūnienė, S Vaitkus, LM Japertienė, S Ryškienė - Medicina, 2008 - mdpi.com
… , where chronic airway mucosal inflammation and remodeling are … the possible associations
of chronic rhinosinusitis with nasal … , systemic inflammation and allergy markers, pulmonary …

Correlation of symptoms, clinical signs, and biomarkers of inflammation in postsurgical chronic rhinosinusitis

SD Racette, RC Wijewickrama… - Annals of Otology …, 2017 - journals.sagepub.com
… data on postsurgical chronic rhinosinusitis patients in 59 … markers are associated with the
cardinal symptoms of CRS. … much inflammation is present but where that inflammation is …

Inflammation and remodelling patterns in early stage chronic rhinosinusitis

N Van Bruaene, K Van Crombruggen… - Clinical & …, 2012 - Wiley Online Library
… -inflammatory, neutrophilic and Th1 markers did not show any difference. These findings
suggest that TGF-beta plays a central role in the initiation of CRSsNP, and represents a major …

Inflammation and endotyping in chronic rhinosinusitis—a paradigm shift

S Ahern, A Cervin - Medicina, 2019 - mdpi.com
… Basic endotyping of inflammatory markers was furthered in this study by the inclusion of
co-morbidities, and classification of cases based on responsiveness to treatment. The inclusion …

Predictive markers of long-term recurrence in chronic rhinosinusitis with nasal polyps

D Rosati, C Rosato, G Pagliuca, B Cerbelli… - American journal of …, 2020 - Elsevier
… We investigate the inflammatory profile in patients with long term recurrent and non-recurrent
CRSwNPs and if a specific profile is associated with recurrence, comparing eosinophilic, …

Clinical and biological markers of difficult-to-treat severe chronic rhinosinusitis

M López-Chacón, J Mullol, L Pujols - Current allergy and asthma reports, 2015 - Springer
Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of
which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal …

Associations between inflammatory endotypes and clinical presentations in chronic rhinosinusitis

WW Stevens, AT Peters, BK Tan, AI Klingler… - The Journal of Allergy …, 2019 - Elsevier
inflammatory patterns by using IFN-γ as a type 1 (T1) marker, Charcot… as T2 markers, and
IL-17A as a type 3 (T3) marker in patients with … We found that inflammation in CRSsNP is highly …