Nonobese diabetic (NOD) mice are a commonly used model of type 1 diabetes (T1D). … Taken
together, our results highlight the systemic perturbations that accompany a loss of glycemic …

… a streptozotocin (STZ)-induced diabetes model in mice systemically overexpressing HO-1
(Tg-HO-1) or mutant HO-1 (Tg-mutHO-1). The diabetic mouse model was induced by multiple …

… Within a week, only MSC-treated diabetic mice exhibited significant reduction in their blood
… in MSC-treated diabetic mice. Furthermore, in those animals albuminuria was reduced and …

… systemic delivery of siRNA specific for gene silencing of TLR4 would reduce cardiomyopathic
changes in a type 1 diabetic mouse model… reduced the myocardial fibrosis in diabetic mice. …

… in diabetic and obese mice after systemic administration of a TNFα-neutralizing antibody
was functionally connected to markedly reduced monocyte/macrophage numbers in ob/ob mice…

… Evaluation of skin from diabetic animals injected with HA revealed also an increase in HA …
that systemic injection may be able to restore the reduced intracellular HA pool of diabetic mice…

… levels in murine models of type 2 diabetes. After 4 weeks of systemic administration of GCCR
ASO to ob/ob mice, a dose-dependent reduction of hepatic GCCR mRNA expression was …

… (NOD) mice. In the present study we administered exogenous IL-18 systemically in 4-wk-old
NOD mice … . Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. …

… As such, we illustrate here that a systemic administration of BHB can increase both
serum and retinal BHB levels in nondiabetic and diabetic mice. Particularly, in the latter …

… treat diabetic db/db mice and to assess the impact of reduced glucagon receptor expression
on the diabetic … We found that chronic treatment with GR-ASO after systemic administration …