Solubility and dissolution enhancement strategies: current understanding and recent trends
… solubility or/and dissolution enhancement of specified drug. … strategies for enhancing drug
solubility and dissolution rate. … of solubility and dissolution rate enhancement but also on the …
solubility and dissolution rate. … of solubility and dissolution rate enhancement but also on the …
[PDF][PDF] Solubility and dissolution enhancement: an overview
VR Babu, SH Areefulla, V Mallikarjun - J Pharm Res, 2010 - Citeseer
… Enhancement of solubility, dissolution rate and bioavailability of drug is a very challenging
… discovered are poorly water soluble drugs. Aqueous solubility of any therapeutically active …
… discovered are poorly water soluble drugs. Aqueous solubility of any therapeutically active …
[PDF][PDF] An overview on the mechanisms of solubility and dissolution rate enhancement in solid dispersion
S Sapkal, M Babhulkar, A Rathi, G Mehetre… - Int J Pharm Tech …, 2013 - researchgate.net
… having poorly aqueous solubility are increasingly … poor solubility [1]. It is well known that
drug efficacy can be severely limited by poor aqueous solubility, leading to low dissolution rate …
drug efficacy can be severely limited by poor aqueous solubility, leading to low dissolution rate …
Enhancement the dissolution rate and solubility of poorly soluble drugs
MA Saleh, SA Mohammed, EC Abdullah… - Advanced Materials …, 2013 - Trans Tech Publ
… API for enhanced solubility, stability, dissolution rate and bioavailability etc. Thermodynamic
and phase diagrams are a powerful and sensitive tool for selecting a useful technique and …
and phase diagrams are a powerful and sensitive tool for selecting a useful technique and …
Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine
J Hecq, M Deleers, D Fanara, H Vranckx… - International journal of …, 2005 - Elsevier
… un-milled NIF clearly shows the dissolution rate enhancement obtained with nano-sized
systems as 95% of the drug is dissolved following 60 min to 5% for the un-milled drug. Complete …
systems as 95% of the drug is dissolved following 60 min to 5% for the un-milled drug. Complete …
Drug nanocrystals: theoretical background of solubility increase and dissolution rate enhancement
D Hasa, B Perissutti, D Voinovich, M Abrami… - Chemical and …, 2014 - hrcak.srce.hr
… that solubility increases with … solubility and dissolution rate. To this end, a thermodynamic
model relating to nanocrystal dimensions (radius), melting temperature/ enthalpy and solubility …
model relating to nanocrystal dimensions (radius), melting temperature/ enthalpy and solubility …
[PDF][PDF] Enhancement of solubility, dissolution rate and bioavailability of BCS Class II Drugs
V Ramesh, S Meenakshi, N Jyothirmayee… - Int J Pharma Chem …, 2016 - academia.edu
… , and bioavailability of poorly water soluble drugs include micronization, chemical … their low
solubility and dissolution rates. They require enhancement in solubility and dissolution rate in …
solubility and dissolution rates. They require enhancement in solubility and dissolution rate in …
[PDF][PDF] Solubility enhancement techniques
VR Vemula, V Lagishetty, S Lingala - International journal of …, 2010 - Citeseer
… The solubility of a poorly water soluble drug can be … in which the drug has good solubility
known as cosolvents.Co-… a solution with enhanced solubility for poorly soluble compounds. …
known as cosolvents.Co-… a solution with enhanced solubility for poorly soluble compounds. …
Study on dissolution rate enhancement of poorly water soluble drug: contributions of solubility enhancement and relatively low micelle diffusivity
VY Joshi, MR Sawant - Journal of dispersion science and …, 2006 - Taylor & Francis
… The objective of this study was to assess the contribution of surfactant-mediated solubility
and micellar diffusivity on the ability of surfactants to enhance drug dissolution. The effect of …
and micellar diffusivity on the ability of surfactants to enhance drug dissolution. The effect of …
Solid dispersions, part I: recent evolutions and future opportunities in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs
DN Bikiaris - Expert opinion on drug delivery, 2011 - Taylor & Francis
… dissolution enhancement of SDs is based on the fact that drugs in the nanoscale range, or in
amorphous phase, dissolve … the drug and the mechanism of dissolution rate enhancement. …
amorphous phase, dissolve … the drug and the mechanism of dissolution rate enhancement. …
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