Solubility and dissolution enhancement strategies: current understanding and recent trends

S Jain, N Patel, S Lin - Drug development and industrial pharmacy, 2015 - Taylor & Francis
solubility or/and dissolution enhancement of specified drug. … strategies for enhancing drug
solubility and dissolution rate. … of solubility and dissolution rate enhancement but also on the …

[PDF][PDF] Solubility and dissolution enhancement: an overview

VR Babu, SH Areefulla, V Mallikarjun - J Pharm Res, 2010 - Citeseer
Enhancement of solubility, dissolution rate and bioavailability of drug is a very challenging
… discovered are poorly water soluble drugs. Aqueous solubility of any therapeutically active …

[PDF][PDF] An overview on the mechanisms of solubility and dissolution rate enhancement in solid dispersion

S Sapkal, M Babhulkar, A Rathi, G Mehetre… - Int J Pharm Tech …, 2013 - researchgate.net
… having poorly aqueous solubility are increasingly … poor solubility [1]. It is well known that
drug efficacy can be severely limited by poor aqueous solubility, leading to low dissolution rate

Enhancement the dissolution rate and solubility of poorly soluble drugs

MA Saleh, SA Mohammed, EC Abdullah… - Advanced Materials …, 2013 - Trans Tech Publ
… API for enhanced solubility, stability, dissolution rate and bioavailability etc. Thermodynamic
and phase diagrams are a powerful and sensitive tool for selecting a useful technique and …

Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine

J Hecq, M Deleers, D Fanara, H Vranckx… - International journal of …, 2005 - Elsevier
… un-milled NIF clearly shows the dissolution rate enhancement obtained with nano-sized
systems as 95% of the drug is dissolved following 60 min to 5% for the un-milled drug. Complete …

Drug nanocrystals: theoretical background of solubility increase and dissolution rate enhancement

D Hasa, B Perissutti, D Voinovich, M Abrami… - Chemical and …, 2014 - hrcak.srce.hr
… that solubility increases with … solubility and dissolution rate. To this end, a thermodynamic
model relating to nanocrystal dimensions (radius), melting temperature/ enthalpy and solubility

[PDF][PDF] Enhancement of solubility, dissolution rate and bioavailability of BCS Class II Drugs

V Ramesh, S Meenakshi, N Jyothirmayee… - Int J Pharma Chem …, 2016 - academia.edu
… , and bioavailability of poorly water soluble drugs include micronization, chemical … their low
solubility and dissolution rates. They require enhancement in solubility and dissolution rate in …

[PDF][PDF] Solubility enhancement techniques

VR Vemula, V Lagishetty, S Lingala - International journal of …, 2010 - Citeseer
… The solubility of a poorly water soluble drug can be … in which the drug has good solubility
known as cosolvents.Co-… a solution with enhanced solubility for poorly soluble compounds. …

Study on dissolution rate enhancement of poorly water soluble drug: contributions of solubility enhancement and relatively low micelle diffusivity

VY Joshi, MR Sawant - Journal of dispersion science and …, 2006 - Taylor & Francis
… The objective of this study was to assess the contribution of surfactant-mediated solubility
and micellar diffusivity on the ability of surfactants to enhance drug dissolution. The effect of …

Solid dispersions, part I: recent evolutions and future opportunities in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs

DN Bikiaris - Expert opinion on drug delivery, 2011 - Taylor & Francis
dissolution enhancement of SDs is based on the fact that drugs in the nanoscale range, or in
amorphous phase, dissolve … the drug and the mechanism of dissolution rate enhancement. …