… in the degradation of p53 [36]. Since we confirmed that PDIA3P1 directly binds to C… EBPβ
to affect the ubiquitination levels of C/EBPβ, we hypothesized that PDIA3P1 may impact C/EBPβ…

… To confirm the degradation of GADD153, we added proteasome inhibitors to MES subtype
cells and found that the expression of GADD153 was augmented (Fig. 4F and Supplementary …

… resistance to radiation, several studies examined the roles of CEBPB and CEBPD in resistance
to the GBM standard of care drug temozolomide… degradation as shown by resistance to …

… Another well-known mechanism of temozolomide resistance is poly (ADP-ribose)
polymerase-1 (PARP-1). This is a base-excision-repair gene, which acts as a first responder in the …

… GBM, consisting of radiotherapy with concomitant temozolomide (TMZ) chemotherapy, also
… (a transcriptional inhibitor of C/EBPβ signaling) degradation. [ 53 ] Accumulating evidence …

… ARPC1B promoted MES phenotype maintenance and radiotherapy resistance by inhibiting
TRIM21-mediated degradation of IFI16 and HuR, thereby activating the NF-κB and STAT3 …

… PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation
to facilitate proneural-tomesenchymal transition. J Exp Clin Cancer Res. 2022 Jul 15; 41 …

… followed by radio- and chemotherapy with temozolomide. The recurrent tumor shows a …
degradation of GADD153, an inhibitor of C/EBPβ transcriptional activity. Furthermore, C/EBPβ …

… /EBPβ induced the transcription of MES genes in GSCs, while suppression of STAT3 and
C/EBPβ … activate autophagy, promote c-Met degradation via K63-linked polyubiquitination, and …

… , invasion, and temozolomide resistance of glioma cells and … to ubiquitin- proteasomal
degradation in IDH1 R132H glioma … the transcription factor C/EBPβ. Front Immunol. 2020;11:657. …