… , suggesting that germline variation influencing mosaic chromosome loss can be detected
3 … Y chromosome loss, and we demonstrate that this approach successfully identifies genes …

… gene variants associate with regulatory changes in the expression of other autosomal genes,
… to greatly increase the identification of genetic variants on chrY, which promises that future …

… , has been considered as a genetic wasteland. Aging-related mosaic loss of ChrY (LOY) has
been … The known risk factors of mosaic LOY including age, genetic variants, ChrY structural …

… Y chromosome variation. The true role of the Y chromosome and associated genetic variants
… Loss of the Y chromosome Loss of the Y chromosome is associated with increased risk of …

… structural variants might have adverse genetic consequences. We also discuss why analysis
of structural variants should become a vital step in any genetic … Gains or losses affecting the …

… the absence of a Y chromosome provides a selective growth … the loss of a putative Y-linked
cell-growth suppressor gene; loss of a … To identify individual genetic variants that underlie this …

… loss of the Y chromosome in a subset of cells while the remainder of cells retain the normal
chromosome… lose all or some portion of the Y chromosome over the course of their lifetime 1 . …

… pregnancy loss. The single most common cause of early (first-trimester) … loss is the presence
of a major fetal chromosomal abnormality, which is responsible for more than 50% of losses …

… summary of the Y chromosome variants defined in this study, … any DAZ gene copy loss
without sY587 SFV loss shows that … the two sY587 sites of each DAZ gene pair. In contrast, the …

… found associations between loss of chromosome Y (LOY) in … phenotypic effects from
postzygotic genetic variation might be … in leukocytes, resulting in loss of statistical power and false-…