… Loss of the Y chromosome (LOY) is one of the most common somatic genomic alterations in
… incidence of myeloid neoplasia-associated genomic alterations. To address this question, …

… We hypothesize that previously described RB1 loss induced genomic instability can affect
any chromosome but selection pressure of growth favoring SCNAs is required for SCNAs to …

… genome alterations, including point mutations, copy number increases and decreases, loss
of … Among these mechanisms, somatic genomic alteration appears to be the major causative …

… to poly (ADP-ribose) polymerase inhibitor olaparib in BRCA2associated prostate cancer
resulting from biallelic BRCA2 reversion mutations restores both germline and somatic loss-of-…

… To distinguish be tween the possible mitotic events (18) that could account for the somatic
losses of constitutional heterozygosity described above, we compared the ratio of the signal …

… scale genomic alterations in somatic cells. Experimental data do demonstrate such genomic
… cells in a human body to cover each day’s loss of more than several tens of millions of cells. …

… A CNA was called for each chromosomal region based on the loss or gain of the following
… any of the 37 genomic alterations reported here that require further genomic study to better …

… The frequency of copy number gain (blue) and loss (red) is shown across the entire genome,
from chromosome 1 on the left to chromosome 22 on the right. Regions of frequent gain …

… genomes are mosaics of somatic … -genome sequencing data to map SVs across 600
tumors and 18 cancers, and investigate the relationship between SVs, copy number alterations (…

… of somatic genetic alterations in BCs from 24 patients with germline pathogenic ATM variants,
and whether somatic loss of … The percentage of the genome altered (copy number, see the …