… to define the mechanism of TMZ resistance and the testing of … and adaptive TMZ resistant
GBM cells have not been … of TMZ resistance in natural and adapted TMZ resistant GBM cell …

… JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of
… and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis. Stem …

… Several Wnt inhibitors, such as salinomycin, celecoxib, and Wnt-C59, have shown restoration
of TMZ sensitivity in resistant GBM cells. These small molecular inhibitors decrease the …

… However, TMZ exposure increased P-gp expression levels in all cell lines. To test the
relevance of this molecule to resistance mechanisms in GBM cells, we applied a TMZ treatment …

… of BER gene NTL1 in SNB19VR cells. In conclusion, we have developed two glioma cell
lines whose distinct mechanisms of acquired resistance to temozolomide, involving expression …

… like phenotype of cancer cells. EMT also leads to the resistance of glioma cells against various
… parental glioma cells and a selected resistance subline with respect to migration abilities. …

… resistance in human malignant gliomas. We firstly developed TMZ-resistant variants of human
glioma cell lines… Protein expression changes associated with acquisition of TMZ resistance …

… tumors become resistant to TMZ. Here, we modeled acquired TMZ resistance in glioma cells
in vitro to identify underlying molecular mechanisms. To this end, the glioma cell lines LNT-…

… Interestingly, silencing of BRCA2 expression was recently found to increase the cytotoxicity
of O 6 -alkylating agents such as temozolomide in GBM cells deficient in MGMT, suggesting …

… Through time, GBM cells become resistant to damages caused by TMZ. This resistance is
related to the implementation of several mechanisms such as DNA repair mechanisms, the …