… on the myometrial excitation–contraction coupling. Wherever possible, we will refer to the
data obtained on human myometrium, resorting to animal models only when human data are …

… The initiation of each phasic contraction of human myometrium is via a tissue-level electrical
discharge that in some experiments demonstrates synchrony at distances greater than 1 cm …

… of myometrium, but the dual model identifies mechanotransduction as relevant to normal
labor. For hydraulic signaling, a local contraction … excitation–contraction coupling and action …

… With this mechanism we simulate the contraction patterns of human labor, and show how
contractions emerge from complex interactions. We explain why the decades-long search for …

… These alterations in the extent of structural and functional coupling are … coupling in the
myometrium during pregnancy and parturition. This chapter will review (1) the basis for contraction …

… Excitation-contraction coupling in myometrium. Electrical activity in the form of action potentials
shapes the intracellular calcium signals and thereby modifies force in the uterus. Altering …

… contraction in the myometrium. Moreover, many of the pathways that mediate the effects
of tocolytic and uterotonic drugs have been identified 11 . However, experimental restrictions…

… leading from excitation to contraction. In the modeling part of … muscle cell (SMC) contraction.
We also present integrative … be applied to modeling myometrial contraction and thus may …

… exhibits a ‘plateau’phase, which contains the peak of the contraction;(6) each contraction
has a phase of diminishing pressure that is approximately symmetrical with the rising phase;(7) …

… These are urgently needed to combat dysfunctions in excitation–contraction coupling that
are clinically challenging, such as preterm labour, slow to progress labours and post-partum …