Tong-Xie-Yao-Fang improves intestinal permeability in diarrhoea-predominant irritable bowel syndrome rats by inhibiting the NF-κB and notch signalling pathways

Q Hou, Y Huang, Z Zhu, L Liao, X Chen, Q Han… - … and alternative medicine, 2019 - Springer
signalling pathway in IBS-D rats Because the Notch signalling pathway plays a key role in
the fate of intestinal epithelial cells [15], we examined the expression of Notch signalling at the …

Intestinal permeability, inflammation and the role of nutrients

R Farré, M Fiorani, S Abdu Rahiman, G Matteoli - Nutrients, 2020 - mdpi.com
… increases systemic endotoxin levels by increasing intestinal permeability, but results are not
pathway occludin and ZO-1 in the small intestinal. Nevertheless, the intestinal permeability

Increased intestinal permeability as a risk factor for type 2 diabetes

AJ Cox, P Zhang, DW Bowden, B Devereaux… - Diabetes & …, 2017 - Elsevier
intestinal permeability and type 2 diabetes (T2D). … signalling cascade that results in
downstream activation of inflammatory signalling pathways and cross-talk with insulin signalling

[HTML][HTML] Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

JR Kelly, PJ Kennedy, JF Cryan, TG Dinan… - Frontiers in cellular …, 2015 - frontiersin.org
… these key signaling pathways has gained traction. Deficits in intestinal permeability may
underpin … Activation of TLRs initiates signal transduction pathways and triggers the expression of …

JAK-STAT pathway regulation of intestinal permeability: pathogenic roles and therapeutic opportunities in inflammatory bowel disease

H Lei, MS Crawford, DF McCole - Pharmaceuticals, 2021 - mdpi.com
… in intestinal permeability and how this plays a key role in resolving intestinal inflammation. …
Variants in genes belonging to the Janus kinase (JAK)—signal transducer and activator of …

[HTML][HTML] Regulation of intestinal permeability: the role of proteases

H Van Spaendonk, H Ceuleers, L Witters… - World journal of …, 2017 - ncbi.nlm.nih.gov
… Indirect inhibition of the effects of MMPs or intervening in the signal transduction pathways
… of intracellular signaling pathways. An increased intestinal permeability is suggested as an …

[HTML][HTML] Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases

SH Lee - Intestinal research, 2015 - synapse.koreamed.org
Intestinal permeability is the property that allows solute and fluid exchange between the
lumen and tissues. Conversely, intestinal … The activation of the MEK/ERK pathway seems to be …

Intestinal permeability–a new target for disease prevention and therapy

SC Bischoff, G Barbara, W Buurman, T Ockhuizen… - BMC …, 2014 - Springer
… associated with increased intestinal permeability such as critically … , intestinal permeability,
which is a feature of intestinal barrier … This triggers a signal transduction pathway involving the …

QingBai decoction regulates intestinal permeability of dextran sulphate sodium‐induced colitis through the modulation of notch and NF‐κB signalling

JC Lin, JQ Wu, F Wang, FY Tang, J Sun, B Xu… - Cell …, 2019 - Wiley Online Library
intestinal mucosal permeability. In addition, cell junction-related proteins and possible signal
pathways … decreased the intestinal permeability by inhibiting NF-κB signalling to regulate …

Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88

S Guo, M Nighot, R Al-Sadi, T Alhmoud… - The Journal of …, 2015 - journals.aai.org
… increase in mouse intestinal permeability was associated … signal transduction axis plays
an important role in regulating the LPS-induced increase in intestinal permeability and intestinal