A perspective on cancer cell metastasis

CL Chaffer, RA Weinberg - science, 2011 - science.org
… Moreover, we know that certain lung cancers metastasize quickly to multiple sites,
whereas others, such as breast and prostate carcinomas, often take years to develop …

Metastatic patterns in squamous cell cancer of the head and neck

C Kotwall, K Sako, MS Razack, U Rao… - The American Journal of …, 1987 - Elsevier
… the incidence of distant metastases in patients with squamous cell cancer of the head and
neck … separate metastatic sites were documented. The average number of metastatic sites per …

Metastatic sites and survival in lung cancer

M Riihimäki, A Hemminki, M Fallah, H Thomsen… - Lung cancer, 2014 - Elsevier
Sites of metastatic spread were identified by their … distribution of metastases and survival in
over 20,000 lung cancer patients. … cancer patients on survival by metastatic site and histology. …

The cellular basis of site-specific tumor metastasis

BR Zetter - New England Journal of Medicine, 1990 - Mass Medical Soc
… Bone is a preferred site of metastasis for neuroblastomas as well as … sites within the brain.
The preference for various metastatic sites differs among different types of leukemic cells, all of …

Targeting metastatic cancer

K Ganesh, J Massague - Nature medicine, 2021 - nature.com
… -small-cell lung, pancreatic and renal cell cancers, among … At metastatic sites, cancer cells
undergo a reverse process of … as a step toward the initiation of metastatic growth 48,49 . EMTs …

Site‐specific metastasis: A cooperation between cancer cells and the metastatic microenvironment

S Izraely, IP Witz - International journal of cancer, 2021 - Wiley Online Library
… organ-specific metastasis. We review the basic principles of site-specific metastasis and the
… DTC and the microenvironment of metastatic sites (metastatic microenvironment [MME]) to …

Molecular interactions in cancer cell metastasis

SA Brooks, HJ Lomax-Browne, TM Carter, CE Kinch… - Acta histochemica, 2010 - Elsevier
Metastasis results from a complex molecular cascade through which cancer cells leave
the site of the primary tumour mass and disseminate to distant anatomical sites where they …

Number of metastatic sites rather than location dictates overall survival of patients with node-negative metastatic renal cell carcinoma

KR Han, AJ Pantuck, MHT Bui, O Shvarts, DG Freitas… - Urology, 2003 - Elsevier
… related to the site of metastases (lung versus bone) and to the number of organ sites
involved (one versus multiple). The most common sites of metastatic renal cell carcinoma (mRCC) …

Number of metastatic sites is a strong predictor of survival in patients with nonsmall cell lung cancer with or without brain metastases

Y Oh, S Taylor, BN Bekele, JM Debnam, PK Allen… - Cancer, 2009 - Wiley Online Library
… a different metastatic site. Second, the space‒occupying effect of metastases would remain
… Of 135 patients who had the CNS as the sole metastatic organ site, 32 had pretreatment …

Impact of the site of metastases on survival in patients with metastatic prostate cancer

G Gandaglia, PI Karakiewicz, A Briganti, NM Passoni… - European urology, 2015 - Elsevier
… with metastatic PCa. To address this void, we sought to evaluate the role of the metastatic
site on … Our hypothesis stated that the occurrence of visceral metastases might represent an …