… B 12 -dependent enzymes methionine synthase and methylmalonyl-… methionine synthase
in cultured cells, pseudovitamin B 12 does not activate the translation of methionine synthase, …

… Methionine synthase catalyzes a methyl transfer from methyltetrahydrofolate to homocysteine,
… by methionine synthase is the terminal reaction in the de novo biosynthesis of methionine; …

… For example, inhibition of methionine synthase (MS) activity leads to accumulation of … In
addition, the activity of cystathionine-β-synthase (CBS) may be stimulated to generate Cys from …

… A closed methionine synthase structure remains to be seen; however, in this study, we have
characterized the ligand-bound opened conformation that we will target by drug design. The …

… methionine synthase activity is required for biological methylations and polyamine production,
via the production of methionine and … Impairment of methionine synthase activity has been …

… , or inhibition of methionine synthase by exposure to nitrous oxide, leads to diminished
activity of this enzyme. In humans, severe inhibition of methionine synthase results in the …

Cobalamin-dependent methionine synthase (MetH) is involved in the process of tumor cell
growth and survival. In this study, a novel series of N 5 -electrophilic substituted …

… mechanism of methionine synthase, and their biological activities were investigated as well.
Compounds (11b, 12b and 16) showed the most active against methionine synthase (IC 50 : …

… inhibits methionine synthase activity in vivo, in cultured mammalian cells. The inhibition of
methionine synthase activity … of [ 14 C]formate into methionine, serine, and purine nucleotides. …

… activity of the MeCbl-dependent enzyme methionine synthase. Methionine synthase specific
activity in … under standard reducing conditions; synthase specific activity in extracts of 5 cblG …