… Summary To clarify the physiological function of pseudovitamin B12 in cyanobacteria, we
determined pseudovitamin B12 contents and cobalamin-dependent methionine synthase …

… pseudovitamin B 12 on the activities of the mammalian vitamin B 12 -dependent enzymes
methionine synthase … cells to determine whether pseudovitamin B 12 functions as an inhibitor …

… To clarify the physiological function of pseudovitamin B 12 (or adeninylcobamide; AdeCba)
in Spirulina platensis NIES-39, cobalamin-dependent methionine synthase (MS) was …

… Neither vitamin B12 nor pseudovitamin B1212 is active in the enzymatic reactions. We
conclude that the coenzyme is a derivative of pseudovitamin B12 containing one or more …

… the coenzyme was a derivative of pseudovitamin B 12 . However, subsequent acid hydrolysis
… , we could replace the adenine in pseudovitamin B 12 and produce the coenzyme form of …

… coenzyme forms of pseudo-vitamin B12 and vitamin B12, it … gues that missing methionine
synthase activity in vitamin B12-deficient … availability of folates for DNA synthesis, the so-called …

… B12 cofactor reactions (which in fact play a destructive role in the Methionine Synthase …
; however, numerous other pseudovitamins are not convertible to biologically active forms of …

… B 12 biosynthetic pathway is characterized by two converging branches: the synthesis of the
corrin ring and the synthesis … Two pathways for corrin ring synthesis have been discovered …

… ”, two organometallic B12-forms are … methionine synthase, and coenzyme B12 (adenosyl-cobalamin),
the cofactor of methylmalonyl-CoA mutase. The cytoplasmatic methionine synthase …

… N5-Methyl-H,-folate would then continue to supply methyl groups for methionine synthesis
until the cobamide on the enzyme was oxidized back to its original inactive form. Activation, or …