… Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing
men. However, the genetic … , we identify 50 independent genetic markers in 46 loci associated …

… how ChrY is prone to loss. Finally, we assess future directions for mosaic LOY studies from
a … In summary, human ChrY may have a magnified effect on men beyond sex determination …

… the loss of genetic variation is a two stage process - loss from within populations and loss …
for a period sufficient for the expression of genetic effects of population turnover. In contrast, …

… mosaic LOY … effects from postzygotic genetic variation might be fundamentally unsound,
especially when considering that the LOY frequency in buccal mucosa and the phenotypic effect …

… mosaic mutations at the base-pair level 21,22,23 . Although each of these studies of mosaic
CNVs, mosaic uniparental disomies, mosaic … that the frequency of mosaic events—both large …

… Genetic procedures for generating genetic mosaics, as … than mosaics), generally involve
the loss of a wild-type gene from a … effect may nonetheless be demonstrated by making use of …

… We used two approaches to map associated genetic variants to genes via expression
effects (eQTLs) in whole blood. First, summary Mendelian randomization (SMR) uses summary-…

… We provide the 14 mLOY-related genetic variants and their effect on lung cancer risk from
our lung cancer GWAS data in Supplementary Table 3. We performed a logistic regression …

… survival from genetic severe disorders that would be lethal in a non-mosaic form. On the
milder end of the spectrum, mosaicism can result in little if any phenotypic effects but increases …

… The aberrant expression of TCL1A or other autosomal genes may exert deleterious effects …
phenotype Unclear Mosaic loss of spermatogenic genes in the gonad Mosaic loss of SHOX in …