Huangqin decoction ameliorates DSS-induced ulcerative colitis: Role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier

M Li, M Li, J Lei, Y Wu, Z Li, L Chen, C Zhou, J Su… - Phytomedicine, 2022 - Elsevier
… In this study, we hypothesized that HQD activates the mTOR pathway and repairs the epithelial
… The regulatory role of amino acid metabolism, mTOR pathway and intestinal epithelial …

Anti-tumour effect of Huangqin Decoction on colorectal cancer mice through microbial butyrate mediated PI3K/Akt pathway suppression

JJ Zhu, HY Liu, LJ Yang, Z Fang… - Journal of Medical …, 2023 - microbiologyresearch.org
… It has been proved that butyrate can suppress the PI3K/Akt pathway, in which Qiao et al. [49]
previously demonstrated the protective role of NaB-induced PI3K/Akt/mTOR pathway

Network Pharmacology–Based Analysis and Experimental Exploration of Antidiabetic Mechanisms of Gegen Qinlian Decoction

Y Xu, J Huang, N Wang, HY Tan, C Zhang… - Frontiers in …, 2021 - frontiersin.org
… Moreover, our results indicated that GQL in T2DM treatment may affect the TNF/NF-κB and
PI3K/AKT/MTOR pathways to reduce inflammation and improve hyperglycemia. Furthermore, …

[PDF][PDF] A network pharmacology approach to investigate the mechanisms of Huangqin decoction in the treatment of irinotecan-induced gastrointestinal toxicity

Y Wang, Q Xu, ZQ Feng - Asian Toxicology Research, 2020 - tmrjournals.cn
… indicated that Huangqin decoction may … of Huangqin decoction play an important role
in the treatment of irinotecan-related gastrointestinal toxicity through multi-target and multi-pathway

Huangqin Decoction regulates autophagy to intervene with intestinal acute graft-versus-host disease in mice

X Cui, X Sun, W Zheng, D Ma - Chinese Journal of Tissue Engineering …, 2022 - cjter.com
… 研究表明,降低 mTOR 水平,增加自噬和降低氧 化应激可影响急性移植物抗宿主病的进程 [17].临床
试验显 示,在标准风险急性移植物抗宿主病的初始治疗中,mTOR 抑制剂雷帕霉素在第 28 天的…

Anti-inflammatory effects of Huangqin decoction on dextran sulfate sodium-induced ulcerative colitis in mice through regulation of the gut microbiota and suppression …

M Li, H Luo, X Wu, Y Liu, Y Gan, N Xu… - Frontiers in …, 2020 - frontiersin.org
… Graphical Abstract This study demonstrated that supplementation of Huangqin decoction
(HQD) … the gut microbiota and suppressing Ras-PI3K-Akt-HIF-1α and NF-κB pathways in mice. …

[HTML][HTML] Huangqi Fuzheng decoction exerts antitumor activity by inhibiting cell growth and inducing cell death in osteosarcoma

J Qin, W Wang, L Sha, L Ge - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Huangqi Fuzheng decoction (HFD) is a traditional Chinese medicine and has been used as
adjuvant clinical therapy for breast, ovarian and thyroid cancer. However, the potential roles …

Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway

PR Wang, JS Wang, C Zhang, XF Song, N Tian… - Journal of …, 2013 - Elsevier
… The decoction was concentrated to dryness on a rotary vacuum evaporator, affording 586.21
g HLJDD (yield: 29.31%), which was stored in refrigerator at 4 C and suspended in 0.5% …

Effects of Huangqin Decoction on ulcerative colitis by targeting estrogen receptor alpha and ameliorating endothelial dysfunction based on system pharmacology

M Li, M Li, N Xu, Z Li, Y Zhang, Y Gan, H Luo… - Journal of …, 2021 - Elsevier
Huangqin decoction (HQD) was originally recorded in Shang Han Lun as a classic TCM
formula of four herbs, the root of Scutellaria baicalensis Georgi. (skullcap, 9 g), Glycyrrhiza …

[HTML][HTML] Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine

MR Ding, YJ Qu, B Hu, HM An - Biomedicine & Pharmacotherapy, 2022 - Elsevier
… from Scutellaria baicalensis Georgi (Huang Qin), which is of … Suan-Zao-Ren decoction (SZRD)
is widely used to treat … components of the mTOR signal pathway and its association …