Formulation and In-vivo Evaluation of Azatanavir Selfnanoemulsifying Drug Delivery System

KD REDDY, P Sandhya, P Mamatha - … Sciences and Drug …, 2022 - ijpsdronline.com
… A novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for improved stability
and oral bioavailability of an oily drug, 1-palmitoyl-2-linoleoyl-3-acetyl-racglycerol. Drug deliv…

Asymmetric synthesis of all stereoisomers of α-methylthreonine using an organocatalytic Steglich rearrangement reaction as a key step

FR Dietz, H Gröger - Synthesis, 2009 - thieme-connect.com
drugs, and numerous methods for their synthesis exist. [³] … β-keto-α-amino acid ester rac-8
using sodium borohydride and … -acetyl-4-methyl-2-phenyloxazol-5-one (7; 52 mg) as an oily

[HTML][HTML] Microfluidics for nano-drug delivery systems: from fundamentals to industrialization

H Zhang, J Yang, R Sun, S Han, Z Yang… - Acta Pharmaceutica Sinica …, 2023 - Elsevier
… nm, consisting of drugs and functional drug nanocarriers prepared … drugs to the desired site
and realize the drugs' sustained release, thereby reducing drugs' toxicity and improving drugs

Development of a Novel Chemoenzymatic Process for 3-(Methylsulfonyl)-l-phenylalanine Phenylmethyl Ester─A Key Intermediate of Lifitegrast (Xiidra)

C Wu, H Guo, J Tang, L Xia, J Shao, Y He… - … Process Research & …, 2024 - ACS Publications
… for the removal of N-acetyl group, 7 different lipases, acylases… converted back to a racemic
mixture (rac)-6 via oxazolone (… The yellow oily liquid 10 was dissolved in EtOAc (1.0 L). Then…

[HTML][HTML] The Impact of Polymers on Enzalutamide Solid Self-Nanoemulsifying Drug Delivery System and Improved Bioavailability

SM Lee, JG Lee, TH Yun, CH Kim, JH Cho, KS Kim - Pharmaceutics, 2024 - mdpi.com
Enzalutamide (ENZ), marketed under the brand name Xtandi ® as a soft capsule, is an
androgen receptor signaling inhibitor drug actively used in clinical settings for treating prostate …

Syntheses of racemic and non-racemic silicon-and germanium-containing α-amino acids of the formula type H2NCH (CH2ElR3) COOH (El= Si, Ge; R= organyl) and …

M Merget, K Günther, M Bernd, E Günther… - Journal of Organometallic …, 2001 - Elsevier
… of the α-amino acids rac-2–rac-6 and on the chromatographic resolutions of rac-2 and …
The solvent was removed under reduced pressure and the oily residue distilled in a Kugelrohr …

Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2

A Nikolaou, MG Kokotou, S Vasilakaki… - Biochimica et Biophysica …, 2019 - Elsevier
… classes of drug targets [1]. Small-molecule enzyme inhibitors have transformed human
medicine and it is estimated to comprise roughly one-third to half of all marketed drugs [2]. Since …

Organosilicon molecules with medicinal applications

AK Franz, SO Wilson - Journal of Medicinal Chemistry, 2013 - ACS Publications
… fluorinated drugs (5-fluorouracil and flucytosine) was investigated, and results demonstrated
that the release of these fluorinated drugs occurs more slowly than a nonfluorinated drug (…

Design, Synthesis and Evaluation of 1, 3-Diaryl Pyrazoles as Inhibitors of GGTase-I, a Target for Anti-Cancer Drugs

M Mansha - 2017 - search.proquest.com
… Proteins modified by GGTase-I include GTPases in the Rho and Rac families, and many G
protein γ subunits. The two CaaX prenyltransferases require the Cys residue fourth from the C-…

Lipase-mediated 'meso-tricks' to transform latently symmetrical d-aldoses into l-aldoses via alditols

GD Gamalevich, BN Morozov, AL Vlasyuk… - Tetrahedron, 1999 - Elsevier
… of antieancer, antiviral and antidiabetes drugs, or else as an … 1-O-acetyl2,3:4,5-di-O-isopropylidene-DL-xylitol
(rac-16a) … combined, and concentrated to leave an oily residue that was …