Characterization reveals a putative epoxide hydrolase from Yarrowia lipolytica with the ability to convert rac-1, 2-epoxyhexane to (R)-diol

VP Godase, NM Kumbhar, SP Govindwar… - Process Biochemistry, 2023 - Elsevier
… This organic layer was dried with salt (magnesium sulphate) and evaporated under reduced
pressure to give an oily residue of hexanediol. The concentrated diol was re-dissolved in …

Nanomedicine for the effective and safe delivery of non-steroidal anti-inflammatory drugs: A review of preclinical research

H Al-Lawati, Z Binkhathlan, A Lavasanifar - European Journal of …, 2019 - Elsevier
… Nanotechnology devices most often increase drug product safety… drug formulations, and/or
by redirecting the drug from normal tissues towards the diseased site. Depending on the drug

The nasal delivery of nanoencapsulated statins–an approach for brain delivery

A Clementino, M Batger, G Garrastazu… - International journal …, 2016 - Taylor & Francis
… signaling proteins Ras, Rho, and Rac. Citation4 Pleiotropic effects of … the drug absorption,
protect the encapsulated drug from … capacity provided by adding an oily core to nanoparticles, …

Enhancement of bioavailability of herbal drugs for treating viral therapy using SNEDDS as the delivery system

R Rajput, S Kaur, Y Ingole, NK Pandey… - BIO Web of …, 2024 - bio-conferences.org
… low bioavailability of drugs for antiviral drugs due to … drugs using Self-Emulsifying lipid
technology. SNEDDS was an isocratic mixture contains an Oil, Surfactant, Co-surfactant, and Drug

Developing inhibitors of the p47phox–p22phox protein–protein interaction by fragment-based drug discovery

SMØ Solbak, J Zang, D Narayanan, LJ Høj… - Journal of Medicinal …, 2020 - ACS Publications
… Thereby, we reveal a new way of targeting p47phox and present the first report of drug-like
molecules with the ability to bind p47phox and inhibit its interaction with p22phox. …

Lipid-based nanoparticle technologies for liver targeting

R Böttger, G Pauli, PH Chao, NAL Fayez… - Advanced drug delivery …, 2020 - Elsevier
drug delivery leading to undesirable systemic side effects. Additionally, depending on the
specific liver disease, drug … developed to passively and actively target drugs to the liver. The …

[Retracted] Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems

B Sharma, S Singh, NJ Siddiqi - BioMed research international, 2014 - Wiley Online Library
… Other drawbacks include the need to administer it by painful intramuscular injection
because of its oily nature. Serious side effects include nephrotoxicity and hypertension. …

Nanocarriers for delivery of taxanes: A review on physicochemical and biological aspects

BR Arruda, MGA Mendes, PGC de Freitas… - Journal of Drug Delivery …, 2023 - Elsevier
… Among these drugs, PTX was the first taxane drug identified in 1967: composed of 17 …
chemotherapy drugs, such as taxanes, partly due solubility enhancement of drugs following …

Spray-dried self-nanoemulsifying drug delivery systems as carriers for the oral delivery of piperine: Characterization and in vitro evaluation

N Kusumorini, AK Nugroho, S Pramono… - Journal of Applied …, 2022 - japsonline.com
… A novel solid selfnanoemulsifying drug delivery system (S-SNEDDS) for improved stability
and oral bioavailability of an oily drug, 1-palmitoyl-2-linoleoyl-3-acetylrac-glycerol. Drug Deliv, …

Diversity-Oriented Synthesis of a Library of Star-Shaped 2H-Imidazolines

X Yu, N Guttenberger, E Fuchs, M Peters… - ACS Combinatorial …, 2015 - ACS Publications
… , the resulting oily residue separated into two phases, whereby the lower phase solidified.
The oily … When we reacted rac-9a with an isocyanate electrophile in order to produce the …