[HTML][HTML] Factors modulating COVID-19: A mechanistic understanding based on the adverse outcome pathway framework

LA Clerbaux, MC Albertini, N Amigo… - Journal of Clinical …, 2022 - mdpi.com
… to clinical outcomes observed in COVID-19 have been … of COVID-19, we evaluated how
those eleven intrinsic and extrinsic factors modulate those processes impacting clinical outcomes

The adverse outcome pathway framework applied to neurological symptoms of COVID-19

HT Hogberg, A Lam, E Ohayon, MA Shahbaz… - Cells, 2022 - mdpi.com
… effects of COVID-19 (eg, Long-COVID) [4,5,6]. Here, we consider evidence using the Adverse
Outcome Pathways (AOP) framework [7] as well as new multiscale pathway perspectives …

Mechanisms leading to gut dysbiosis in COVID-19: current evidence and uncertainties based on adverse outcome pathways

LA Clerbaux, J Filipovska, A Muñoz, M Petrillo… - Journal of clinical …, 2022 - mdpi.com
… Particularly, COVID-19 is markedly heterogeneous in terms of clinical outcomes, with a high
variation at the individual level. Poor clinical outcomes in COVID-19 patients were notably …

Systematic organization of COVID-19 data supported by the adverse outcome pathway framework

P Nymark, M Sachana, SB Leite, J Sund… - Frontiers in public …, 2021 - frontiersin.org
… description of COVID-19 [https://www.wikipathways.org/index.php/Pathway:… to COVID-19
(14). These initial efforts have focused on the most frequently reported outcomes of COVID-19, …

[HTML][HTML] COVID-19 through adverse outcome pathways: Building networks to better understand the disease–3rd CIAO AOP design workshop

LA Clerbaux, N Amigó, MJ Amorim, A Bal-Price… - Altex, 2022 - ncbi.nlm.nih.gov
… biological nodes involved in multiple outcomes observed in COVID-19 patients. During the
… consolidated, integrating viral variants and long COVID when relevant, while an outreach …

COVID-19 and the liver: an adverse outcome pathway perspective

M Vinken - Toxicology, 2021 - Elsevier
… Liver damage is observed in up to half of hospitalized COVID-19 patients and can result …
an adverse outcome pathway construct that mechanistically describes the pathways induced by …

Mechanistic understanding of the olfactory neuroepithelium involvement leading to short-term anosmia in COVID-19 using the adverse outcome pathway framework

MA Shahbaz, F De Bernardi, A Alatalo, M Sachana… - Cells, 2022 - mdpi.com
outcome pathway (AOP) framework, well established in toxicology, to propose a sequence of
measurable key events (KEs) leading to short-term anosmia in COVID-19. … follow COVID-19

Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19

MW Henderson, F Lima, CRP Moraes, A Ilich… - Blood …, 2022 - ashpublications.org
COVID-19, we used a recently described strategy to assess activation of the contact and
intrinsic pathways 25 and also measured MVTF levels as a biomarker of extrinsic pathway

[HTML][HTML] Advanced adverse outcome pathways potentially bridging the pathogenesis of COVID-19

CG Park, SR Lim, I Jun, YO Lee - 2021 - europepmc.org
outcome pathway (AOP) framework to support re-search on the pathogenesis of viral disease.
We first constructed adverse outcome pathways (AOPs) applicable to COVID-19pathway

COVID-19 pandemic and STEMI: pathway activation and outcomes from the pan-London heart attack group

CD Little, T Kotecha, L Candilio, RJ Jabbour… - Open …, 2020 - openheart.bmj.com
… Data and outcomes from 2020 were compared with the same time period … outcomes of
patients with STEMI with active COVID-19 against those of patients with STEMI without COVID-19. …