Outcome after traumatic brain injury: pathway analysis of contributions from premorbid, injury severity, and recovery variables

TA Novack, BA Bush, JM Meythaler… - Archives of physical …, 2001 - Elsevier
… premorbid variables, injury severity, and cognitive and functional status to outcome 1 year
after traumatic brain injury (TBI) and to assess the feasibility of multivariate path analysis as a …

Analysis of functional pathways altered after mild traumatic brain injury

JB Redell, AN Moore, RJ Grill, D Johnson… - Journal of …, 2013 - liebertpub.com
… Concussive injury (or mild traumatic brain injury; mTBI) can exhibit features of focal or diffuse
injuryPathway analysis indicated that several molecules involved in both Mip-1α and IL-6 …

Systems biology approaches for discovering biomarkers for traumatic brain injury

JD Feala, MDM AbdulHameed, C Yu, B Dutta… - Journal of …, 2013 - liebertpub.com
brain injury. One possibility is to apply emerging systems biology strategies to holistically
probe and analyze the complex interweaving molecular pathways … and pathway analysis to a …

Phenotyping the spectrum of traumatic brain injury: a review and pathway to standardization

MJ Pugh, E Kennedy, EM Prager… - Journal of …, 2021 - liebertpub.com
… Conceptual overview of the progression and divergence of traumatic brain injury (TBI)
phenotypes. TBI phenotypes (rectangles) emerge statistically (1–4) from the presence and …

Traumatic brain injury induces long-lasting changes in immune and regenerative signaling

DR Boone, HA Weisz, HE Willey, KEO Torres… - PLoS …, 2019 - journals.plos.org
… There are no existing treatments for the long-term degenerative effects of traumatic brain
injury (TBI). … Here, we used microarray and pathway analyses to interrogate TBI-induced gene …

Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response

TE White, GD Ford, MC Surles-Zeigler, AS Gates… - Bmc Genomics, 2013 - Springer
… In the current study, we used gene microarray analysis to determine which genes, pathways
and … The use of multiple network and pathway analyses to identify GOI aided in making our …

Modulation of the cAMP signaling pathway after traumatic brain injury

CM Atkins, AA Oliva Jr, OF Alonso, DD Pearse… - Experimental …, 2007 - Elsevier
… the initial injury. Using a clinically relevant model of TBI, the parasagittal fluid-… brain injury
(FPI) model, we found injury-induced impairments in the cyclic AMP (cAMP) signaling pathway. …

Effect of a clinical pathway for severe traumatic brain injury on resource utilization

DA Spain, LH McIlvoy, SE Fix, EH Carrillo… - Journal of Trauma …, 1998 - journals.lww.com
… The usefulness of clinical pathways for the complex trauma patient is unclear. We analyzed
the effect of a clinical pathway for severe traumatic brain injury (TBI) on resource utilization. …

Development and implementation of a clinical pathway for severe traumatic brain injury

TW Vitaz, L McIlvoy, GH Raque, D Spain… - Journal of Trauma …, 2001 - journals.lww.com
… Such pathways do not limit physician decision-making … Our traumatic brain injury clinical
pathway (TBI-CP) was developed … The goal of the pathway was to standardize patient care and …

Understanding outcomes based on the post-acute hospitalization pathways followed by persons with traumatic brain injury

D Mellick, KA Gerhart, GG Whiteneck - Brain injury, 2003 - Taylor & Francis
… the factors that determine the pathways of care people with traumatic brain injury (TBI) follow
after acute care discharge, and to identify differences in outcome based on those pathways. …