Progressive neurodegeneration across chronic stages of severe traumatic brain injury

Z Belchev, A Gilboa, M Binns, B Colella… - The Journal of Head …, 2022 - journals.lww.com
… traumatic brain injury (TBI) typically focuses on the immediate, postimpact primary injuries
… have revealed progressive losses to brain volume (including whole brain and substructures…

Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury

AI Faden, J Wu, BA Stoica… - British journal of …, 2016 - Wiley Online Library
… Traumatic brain injury (TBI) has been linked to dementia and chronic … can cause
progressive neurodegeneration that may be treatable even weeks after traumatic injury. …

Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

NSN Graham, DJ Sharp - Journal of Neurology, Neurosurgery & …, 2019 - jnnp.bmj.com
… which arise from progressive neurodegenerative pathologies. Disentangling the direct effects
of TBI from those of a slowly progressive neurodegenerative process using clinical history …

Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans

S Bagnato, C Boccagni - Neural regeneration research, 2020 - journals.lww.com
Traumatic brain injury (TBI) is the paradigmatic example of acute brain injury, defined as
sudden and unexpected structural and/or functional damage to the brain. In western countries, …

Traumatic brain injury and risk of neurodegenerative disorder

BL Brett, RC Gardner, J Godbout, K Dams-O'Connor… - Biological …, 2022 - Elsevier
neurodegeneration. We review the evidence for TBI as a risk factor for neurodegenerative
… Further, we describe the dynamic interactions between acute response to injury and chronic …

Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury

NSN Graham, KA Zimmerman, F Moro… - Science translational …, 2021 - science.org
Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …

Mild traumatic brain injury: a risk factor for neurodegeneration

BE Gavett, RA Stern, RC Cantu, CJ Nowinski… - Alzheimer's research & …, 2010 - Springer
… Recently, it has become clear that head trauma can lead to a progressive neurodegeneration
known as chronic traumatic encephalopathy. Although the medical literature also …

Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation

DJ Loane, A Kumar, BA Stoica… - … of Neuropathology & …, 2014 - academic.oup.com
… Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known …

Traumatic brain injury: a risk factor for neurodegenerative diseases

R Gupta, N Sen - Reviews in the Neurosciences, 2016 - degruyter.com
brain injury (TBI) may be defined as ‘an alteration in brainBrain injuries can be classified
into mild, moderate, and severe … , is a progressive neurodegenerative disease that affects …

Diffuse axonal injury predicts neurodegeneration after moderate–severe traumatic brain injury

NSN Graham, A Jolly, K Zimmerman, NJ Bourke… - Brain, 2020 - academic.oup.com
… Furthermore, we assess the relative importance of different predictors of progressive
neurodegeneration to establish the specificity of DTI measures of DAI, and test whether FA explains …