Progressive neurodegeneration across chronic stages of severe traumatic brain injury
… traumatic brain injury (TBI) typically focuses on the immediate, postimpact primary injuries
… have revealed progressive losses to brain volume (including whole brain and substructures…
… have revealed progressive losses to brain volume (including whole brain and substructures…
Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury
… Traumatic brain injury (TBI) has been linked to dementia and chronic … can cause
progressive neurodegeneration that may be treatable even weeks after traumatic injury. …
progressive neurodegeneration that may be treatable even weeks after traumatic injury. …
Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia
NSN Graham, DJ Sharp - Journal of Neurology, Neurosurgery & …, 2019 - jnnp.bmj.com
… which arise from progressive neurodegenerative pathologies. Disentangling the direct effects
of TBI from those of a slowly progressive neurodegenerative process using clinical history …
of TBI from those of a slowly progressive neurodegenerative process using clinical history …
Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans
S Bagnato, C Boccagni - Neural regeneration research, 2020 - journals.lww.com
Traumatic brain injury (TBI) is the paradigmatic example of acute brain injury, defined as
sudden and unexpected structural and/or functional damage to the brain. In western countries, …
sudden and unexpected structural and/or functional damage to the brain. In western countries, …
Traumatic brain injury and risk of neurodegenerative disorder
… neurodegeneration. We review the evidence for TBI as a risk factor for neurodegenerative
… Further, we describe the dynamic interactions between acute response to injury and chronic …
… Further, we describe the dynamic interactions between acute response to injury and chronic …
Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury
Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …
Mild traumatic brain injury: a risk factor for neurodegeneration
… Recently, it has become clear that head trauma can lead to a progressive neurodegeneration
known as chronic traumatic encephalopathy. Although the medical literature also …
known as chronic traumatic encephalopathy. Although the medical literature also …
Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation
… Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known …
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known …
Traumatic brain injury: a risk factor for neurodegenerative diseases
… brain injury (TBI) may be defined as ‘an alteration in brain … Brain injuries can be classified
into mild, moderate, and severe … , is a progressive neurodegenerative disease that affects …
into mild, moderate, and severe … , is a progressive neurodegenerative disease that affects …
Diffuse axonal injury predicts neurodegeneration after moderate–severe traumatic brain injury
… Furthermore, we assess the relative importance of different predictors of progressive
neurodegeneration to establish the specificity of DTI measures of DAI, and test whether FA explains …
neurodegeneration to establish the specificity of DTI measures of DAI, and test whether FA explains …
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