When FESS fails: the inflammatory load hypothesis in refractory chronic rhinosinusitis

A Bassiouni, Y Naidoo, PJ Wormald - The Laryngoscope, 2012 - Wiley Online Library
Through recent advances in research, our understanding of chronic rhinosinusitis (CRS) has
evolved to consider it as an inflammatory condition of the mucosa brought about by multiple …

Refractory chronic rhinosinusitis with nasal polyposis

BP Hull, RK Chandra - Otolaryngologic Clinics of North America, 2017 - oto.theclinics.com
Chronic rhinosinusitis (CRS) describes the family of disease … chronic rhinosinusitis without
nasal polyposis (CRSsNP). This article discusses various forms of CRSwNP that are refractory

Management of refractory chronic rhinosinusitis in children

ND Adappa, JM Coticchia - American journal of otolaryngology, 2006 - Elsevier
OBJECTIVE: Pediatric chronic rhinosinusitis (CRS) continues to be a difficult problem for the
medical community. Traditionally, oral antibiotic therapy has been the cornerstone of …

Surgical therapy vs continued medical therapy for medically refractory chronic rhinosinusitis: a systematic review and meta‐analysis

ZM Patel, A Thamboo, L Rudmik… - International forum of …, 2017 - Wiley Online Library
… The currently accepted treatment paradigm of treating chronic rhinosinusitis (CRS) first with
appropriate medical therapy (AMT) and then with surgery if patients are refractory to AMT, …

Refractory chronic rhinosinusitis: pathophysiology and management of chronic rhinosinusitis persisting after endoscopic sinus surgery

M Desrosiers - Current allergy and asthma reports, 2004 - Springer
Refractory chronic rhinosinusitis (RCRS) is defined as persistence of signs and symptoms
of chronic rhinosinusitis, despite technically adequate endoscopic sinus surgery. Rather than …

Analysis of comorbidities and objective parameters in refractory chronic rhinosinusitis

PS Batra, L Tong, MJ Citardi - The Laryngoscope, 2013 - Wiley Online Library
Objectives/Hypothesis The objective of this study was to construct the clinical profile of
patients with chronic rhinosinusitis (CRS) with/without polyposis undergoing revision sinus …

Productivity costs in patients with refractory chronic rhinosinusitis

L Rudmik, TL Smith, RJ Schlosser… - The …, 2014 - Wiley Online Library
… The purpose of this study was to: 1) define the annual productivity cost for a patient with
refractory chronic rhinosinusitis (CRS) and 2) evaluate the relationship between degree of …

Impact of continued medical therapy in patients with refractory chronic rhinosinusitis

KA Smith, L Rudmik - International forum of allergy & rhinology, 2014 - Wiley Online Library
Chronic rhinosinusitis (CRS) is a ubiquitous inflammatory disease with an estimated …
Refractory chronic rhinosinusitis (RCRS) patients represent a subset of patients with CRS …

Endoscopic sinus surgery compared to continued medical therapy for patients with refractory chronic rhinosinusitis

KA Smith, TL Smith, JC Mace… - International forum of …, 2014 - Wiley Online Library
… in patients with refractory chronic rhinosinusitis (CRS). The objective of this study was to
evaluate continued medical therapy vs ESS for patients with refractory CRS who have severe …

Quality of life of patients with refractory chronic rhinosinusitis: effects of filgrastim treatment

M van Agthoven, WJ Fokkens… - American journal of …, 2001 - journals.sagepub.com
In this double-blind placebo-controlled randomized clinical trial, we investigated the influence
of filgrastim administration on the quality of life (QOL) of refractory chronic sinusitis patients …