Aim Ischaemia–reperfusion injury is associated with reduced bioavailability of nitric oxide
(NO) and microvascular dysfunction. One emerging mechanism behind reduced NO …

Aims Nitric oxide (NO) is vital for the integrity of the cardiovascular system and protection
against ischaemic heart disease. Arginase is up-regulated during ischaemia–reperfusion …

Reduced bioavailability of nitric oxide (NO) contributes to the development of myocardial
ischemia-reperfusion (I/R) injury. Increased activity of arginase is a potential factor that …

Consumption of L-arginine contributes to reduced bioavailability of nitric oxide (NO) that is
critical for the development of ischemia-reperfusion injury. The aim of the study was to …

ABSTRACT A reduction in L‐arginine availability has been implicated in the impairment of
endothelium‐dependent nitric oxide (NO)‐mediated vasodilation by ischemia‐reperfusion …

Two distinct enzymes of arginase (1 and 2) are critically regulating nitric oxide (NO)
bioavailability by competing with NO synthase for their common substrate l-arginine …

Background Arginase competes with nitric oxide synthase for their common substrate L-
arginine. Up-regulation of arginase in coronary artery disease (CAD) and diabetes mellitus …

BACKGROUND: Chronic myocardial ischemia induces endothelial dysfunction in the
coronary microcirculation resulting in impaired nitric oxide signaling. This dysfunction has …

Background—We tested whether tumor necrosis factor (TNF)-α increases arginase
expression in endothelial cells as one of the primary mechanisms by which this inflammatory …

Background—Endothelial dysfunction plays an important role in the early development of
atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased …