Strategies for improving the payload of small molecular drugs in polymeric micelles

Y Zhang, T Ren, J Gou, L Zhang, X Tao, B Tian… - Journal of Controlled …, 2017 - Elsevier
In the past few years, substantial efforts have been made in the design and preparation of
polymeric micelles as novel drug delivery vehicles. Typically, polymeric micelles possess a …

Polymeric micelles as drug delivery vehicles

Z Ahmad, A Shah, M Siddiq, HB Kraatz - Rsc Advances, 2014 - pubs.rsc.org
Though much progress has been made in drug delivery systems, the design of a suitable
carrier for the delivery of hydrophobic drugs is still a major challenge for researchers. The …

Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs

Y Lu, K Park - International journal of pharmaceutics, 2013 - Elsevier
Poorly soluble drugs often encounter low bioavailability and erratic absorption patterns in
the clinical setting. Due to the rising number of compounds having solubility issues, finding …

Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

[HTML][HTML] New advances in biomedical application of polymeric micelles

A Figueiras, C Domingues, I Jarak, AI Santos, A Parra… - Pharmaceutics, 2022 - mdpi.com
In the last decade, nanomedicine has arisen as an emergent area of medicine, which
studies nanometric systems, namely polymeric micelles (PMs), that increase the solubility …

Role of non-covalent and covalent interactions in cargo loading capacity and stability of polymeric micelles

X Ke, VWL Ng, RJ Ono, JMW Chan… - Journal of Controlled …, 2014 - Elsevier
Polymeric micelles self-assembled from biodegradable amphiphilic block copolymers have
been proven to be effective drug delivery carriers that reduce the toxicity and enhance the …

Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle–cell interaction

S Kim, Y Shi, JY Kim, K Park… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance of the field: Spontaneously constructed from block copolymers in aqueous
media, the polymer micelle has been extensively studied as a potential carrier of poorly …

Polymeric micelles: A ray of hope among new drug delivery systems

A Kapse, N Anup, V Patel, GK Saraogi, DK Mishra… - Drug Delivery …, 2020 - Elsevier
In this fast-growing nanotechnological drug delivery era the focus is narrowing to real
nanocarriers that can be commercialized to improve human healthcare. Many nanocarriers …

Rational design of polymeric micelles for targeted therapeutic delivery

Y Zheng, Y Oz, Y Gu, N Ahamad, K Shariati… - Nano Today, 2024 - Elsevier
Polymeric micellar drug carriers have emerged as effective tools to enhance the solubility
and bioavailability of hydrophobic drugs. These micelles possess a nano size structure that …

Strategies to improve micelle stability for drug delivery

Y Lu, E Zhang, J Yang, Z Cao - Nano research, 2018 - Springer
Micelles have been studied as drug delivery carriers for decades. Their use can potentially
result in high drug accumulation at the target site through the enhanced permeability and …