New insights into the pathogenesis and management of rheumatoid arthritis

S Jin, J Zhao, M Li, X Zeng - Chronic Diseases and Translational …, 2022 - mednexus.org
Over the past few decades, understanding of the pathogenesis of rheumatoid arthritis (RA)
has improved substantially. Insights into the cellular and molecular mechanisms involved in …

Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Translating basic research into clinical rheumatology

D van der Woude, TWJ Huizinga - Best Practice & Research Clinical …, 2008 - Elsevier
Findings from basic research in combination with precise clinical observations of the
disease course in rheumatoid arthritis (RA) have led to the development of a multistage …

Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies

Q Guo, Y Wang, D Xu, J Nossent, NJ Pavlos, J Xu - Bone research, 2018 - nature.com
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the lining of the synovial joints and is associated with progressive disability, premature …

Etiology and risk factors for rheumatoid arthritis: a state-of-the-art review

VC Romão, JE Fonseca - Frontiers in medicine, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis

S Liu, H Ma, H Zhang, C Deng, P Xin - Clinical Immunology, 2021 - Elsevier
Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction
in which imbalances in pro-inflammatory and anti-inflammatory cytokines promote the …

Rheumatoid arthritis therapy: advances from bench to bedside

SI Choi, E Brahn - Autoimmunity, 2010 - Taylor & Francis
Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with significant
functional disability and morbidity. Treatment with conventional disease-modifying anti …

Promising therapeutic targets for treatment of rheumatoid arthritis

J Huang, X Fu, X Chen, Z Li, Y Huang… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

A Review of Proposed Mechanisms in Rheumatoid Arthritis and Therapeutic Strategies for the Disease

R Mohite, G Doshi - Endocrine, Metabolic & Immune Disorders …, 2024 - ingentaconnect.com
Rheumatoid arthritis (RA) is characterized by synovial edema, inflammation, bone and
cartilage loss, and joint degradation. Patients experience swelling, stiffness, pain, limited …

[PDF][PDF] One year in review 2018: pathogenesis of rheumatoid arthritis

E Calabresi, F Petrelli, AF Bonifacio… - Clin Exp …, 2018 - clinexprheumatol.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily
affects joints. The several mechanisms involved in the development of the disease are not …