Clonal expansions of mutated hematopoietic cells, termed clonal hematopoiesis, are
common in aging humans. One expected consequence of mutation-associated clonal …

Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …

Traditional risk factors are incompletely predictive of cardiovascular disease development, a
leading cause of death in the elderly. Recent epidemiological studies have shown that …

Acquired genetic or cytogenetic alterations in a blood stem cell that confer clonal fitness
promote its relative expansion leading to clonal hematopoiesis (CH). Despite a largely intact …

Clonal hematopoiesis arises from somatic mutations that provide a fitness advantage to
hematopoietic stem cells and the outgrowth of clones of blood cells. Clonal hematopoiesis …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Ageing and inflammation strongly drive the risk of cardiovascular disease. Work over the
past decade has uncovered a common condition characterized by the positive selection of …

The accumulation of somatic mutations in hematopoietic stem cells during aging, leading to
clonal expansion, is linked to a higher risk of cardiovascular mortality and hematologic …

Background The incidence of hematologic cancers increases with age. These cancers are
associated with recurrent somatic mutations in specific genes. We hypothesized that such …

Increasing evidence shows that conventional cardiovascular risk factors are incompletely
predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there …