Gene therapy, used to achieve functional recovery from sensorineural deafness, promises to
grant better understanding of the underlying molecular and genetic mechanisms that …

Cochlear gene therapy has made tremendous strides over the past 5 years. The first study
documenting successful restoration of congenital hearing loss using AAV-mediated gene …

Inner ear gene therapy has recently effectively restored hearing in neonatal mice, but it is
complicated in adulthood by the structural inaccessibility of the cochlea, which is embedded …

Mice present an ideal model for inner ear gene therapy because their genome is being
rapidly sequenced, their generation time is relatively short, and they serve as a valuable …

Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to
loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of …

Cochlear gene transfer studies in animal models have utilized mainly two delivery methods:
direct injection through the round window membrane (RWM) or intracochlear infusion …

Inner ear gene therapy offers great potential as a treatment for hearing loss and dizziness.
The surgical method used to deliver gene therapy into the inner ear is a critical step in …

Inner ear gene therapy offers great promise as a potential treatment for hearing loss and
dizziness. One of the critical determinants of the success of inner ear gene therapy is to find …

Murine models are ideal for studying cochlear gene transfer, as many hearing loss-related
mutations have been discovered and mapped within the mouse genome. However, because …

© The American Society of Gene & Cell Therapy commentary chicken-actin promoter
demonstrated exclusive inner hair cell expression. This observation led the investigators to …