Influenza is a seasonal and serious health threat, and the recent outbreak of H7N9 following
the pandemic spread of H1N1 in 2009 has served to emphasize the importance of anti …

Seasonal and pandemic influenza have caused high morbidity and mortality worldwide.
Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern …

Introduction: The 2009-H1N1 influenza pandemic has prompted new global efforts to
develop new drugs and drug design techniques to combat influenza viruses. While there …

Influenza A is an acute respiratory infectious disease caused by the influenza A virus, which
seriously threatens global human health and causes substantial economic losses every …

Highlights•No new influenza A antivirals have gained global approval for nearly two
decades.•Due to influenza A evolution more antiviral options are needed.•Promising anti …

Introduction: The emergence of the highly pathogenic avian influenza (HPAI) H5N1 virus
and the recent global circulation of H1N1 swine-origin influenza virus in 2009 have …

Conclusion In the past 10 years, great progress has been made in the application of
orthogonal and newly emerging strategies to facilitate anti-influenza lead discovery and …

Pandemic (H1N1) influenza poses an imminent threat. Nations have stockpiled inhibitors of
the influenza protein neuraminidase in hopes of protecting their citizens, but drug-resistant …

We present a novel algorithm called CrystalDock that analyzes a molecular pocket of
interest and identifies potential binding fragments. The program first identifies groups of …

Introduction: Influenza antiviral high-throughput screens have been extensive, and yet no
approved influenza antivirals have been identified through high-throughput screening. This …