Radiotherapy is an important therapeutic option for the treatment of cancer. Growing
evidence indicates that, besides inducing an irreversible DNA damage, radiotherapy …

Radiotherapy is an important treatment for cancer. The main mode of action is thought to be
the irreversible damage to tumor cell DNA, but there is evidence that irradiation mobilizes …

Radiotherapy (RT) with ionizing irradiation is commonly used to locally attack tumors. It
induces a stop of cancer cell proliferation and finally leads to tumor cell death. During the …

Radiotherapy is an important cornerstone in cancer treatment. Ionizing gamma-irradiation is
capable of inducing DNA damage and consequential cell death in a precise and effective …

The last decade has witnessed significant progress in the field of cancer immunotherapy.
This has, in part, been driven by a growing recognition that elements of the innate immune …

Ionizing radiation (IR) is a powerful therapeutic modality for cancer, commonly used for its
capacity to kill cancer cells. In this Frontiers Research Topic Book radiotherapy effects are re …

Radiotherapy, primarily known for its cytotoxic effect on the tumor cells, via the induction of
DNA damages, has the ability to induce a systemic antitumoral response. By an …

Radiotherapy has extensively been employed as a curative or palliative intervention against
cancer throughout the last century, with a varying degree of success. For a long time, the …

The therapy of cancer emerged as multimodal treatment strategy. The major mode of action
of locally applied radiotherapy (RT) is the induction of DNA damage that triggers a network …

Radiotherapy (RT) primarily aims to locally destroy the tumor via the induction of DNA
damage in the tumor cells. However, the so-called abscopal, namely systemic and immune …