Copper (Cu) and other transition metals are essential for living organisms but also toxic
when present in excess. To cope with this apparent paradox, organisms have developed …

Key message The mitochondrial metallochaperone COX19 influences iron and copper
responses highlighting a role of mitochondria in modulating metal homeostasis in …

We have identified a new plant gene, AtCOX17, encoding a protein that shares sequence
similarity to COX17, a Cu-binding protein from yeast (Saccharomyces cerevisiae) and …

Mitochondria contain two enzymes, Cu, Zn superoxide dismutase (Sod1) and cytochrome c
oxidase (CcO), that require copper as a cofactor for their biological activity. The copper used …

Metals are essential elements of all living organisms. Among them, copper is required for a
multiplicity of functions including mitochondrial oxidative phosphorylation and protection …

All known eukaryotes require copper for their development and survival. The essentiality of
copper reflects its widespread use as a co-factor in conserved enzymes that catalyze …

The primary function of mitochondria is respiration, where catabolism of substrates is
coupled to ATP synthesis via oxidative phosphorylation. In plants, mitochondrial composition …

As a result of copper essentiality for life, plants and most other organisms have developed a
conserved and complex network of proteins to handling Cu in order to prevent its deficit and …

Understanding the metal ion content of plant mitochondria and metal ion interactions with
the proteome are vital for insights into both normal respiratory function and the process of …

Metallochaperones traffic copper (Cu+) from its point of entry at the plasma membrane to its
destination. In plants, one destination is the chloroplast, which houses plastocyanin, a Cu …