Thapsigargin induces an endothelium-dependent, intracellular calcium ion-dependent vasodilation in vitro

S Matsuyama, H Shuntoh, S Katayama, C Tanaka - Life sciences, 1993 - Elsevier
The effect of thapsigargin, a specific inhibitor of intracellular Ca 2+-ATPases, on
endothelium-dependent relaxation was studied in the guinea pig thoracic aorta …

Role of endothelium in thapsigargin-induced arterial responses in rat aorta

Y Huang, X Yao, CW Lau, FL Chan, NWK Chan… - European journal of …, 2000 - Elsevier
We assessed the role of endothelium in the arterial response to thapsigargin, the Ca2+-
ATPase inhibitor of the endoplasmic reticulum, in rat isolated aortic rings. Thapsigargin …

Thapsigargin inhibits the response to acetylcholine and substance P but does not interfere with the responses to endothelium-independent agents

S Amerini, S Filippi, A Parenti, M Ziche… - Journal of …, 1996 - journals.lww.com
We investigated the influence of the Ca 2+-ATPase inhibitor thapsigargin (TG) on the
vasorelaxant response to different endothelium-dependent and endothelium-independent …

Possible Involvement of Ca2+ Entry and its Pharmacological Characteristics Responsible for Endothelium‐dependent, NO‐mediated Relaxation Induced by …

H Taniguchi, H Hirano, Y Tanaka… - Journal of pharmacy …, 1999 - Wiley Online Library
Thapsigargin, a specific inhibitor of Ca2+‐pump Ca2+‐ATPase in the sarcoplasmic/
endoplasmic reticulum (SR/ER), produces an endothelium‐dependent vascular relaxation …

Effects of thapsigargin in isolated rat thoracic aorta

EO Mikkelsen, O Thastrup… - Pharmacology & …, 1988 - Wiley Online Library
The effect of thapsigargin (Tg) was studied in rat thoracic aorta. Tg (10‐8—10‐5 M) had a
dual effect on rat aorta. Thus, Tg induced a concentration dependent increase in basal tone …

Endothelium mediated vasorelaxant effects of Ca (2+)-ATPase inhibitors on thoracic aorta from neonatal and adult guinea pigs.

H Tanaka, H Taniguchi, N Agata, Y Tanaka… - Research …, 1997 - europepmc.org
Vasorelaxant effects of Ca (2+)-ATPase inhibitors were examined in the isolated adult and
neonatal guinea pig thoracic aorta focusing on the functional alterations of endothelial cells …

Increased contractile response induced with ouabain is abolished by thapsigargin in aorta of renal hypertensive rats.

PI Ceron, LM Bendhack - General pharmacology, 1997 - europepmc.org
1. The aim of the present study was to test in vitro if the increased contractile effect of
phenylephrine and KCl, observed after the addition of ouabain in renal hypertensive rat …

Inhibition by SK&F96365 of NO-mediated relaxation induced by Ca2 (+)-ATPase inhibitors in rat thoracic aorta.

H Moritoki, T Hisayama, S Takeuchi… - British journal of …, 1996 - ncbi.nlm.nih.gov
We investigated the effect of SK&F96365, a putative inhibitor of receptor-operated Ca2+
entry, on the endothelium-dependent, NO-mediated relaxation and cyclic GMP formation …

Thapsigargin inhibits angiogenesis in the rat isolated aorta: studies on the role of intracellular calcium pools

N Shukla, N Freeman, P Gadsdon… - Cardiovascular …, 2001 - academic.oup.com
Objective: Since the role of Ca2+ in angiogenesis is not fully understood, we investigated
the effect of thapsigargin (TG: depletes intracellular Ca2+ pools) and other Ca2+ modulators …

Selective inhibition of agonist-induced but not shear stress-dependent release of endothelial autacoids by thapsigargin.

H Macarthur, M Hecker, R Busse… - British journal of …, 1993 - ncbi.nlm.nih.gov
The effects of the Ca (2+)-ATPase inhibitor, thapsigargin, on the shear stress-dependent and
on the agonist-stimulated release of endothelium-derived relaxing factor, ie nitric oxide (NO) …