Converged avenues: depression and Alzheimer's disease–shared pathophysiology and novel therapeutics

S Bajaj, R Mahesh - Molecular Biology Reports, 2024 - Springer
Depression, a highly prevalent disorder affecting over 280 million people worldwide, is
comorbid with many neurological disorders, particularly Alzheimer's disease (AD) …

The putative neurodegenerative links between depression and Alzheimer's disease

S Wuwongse, RCC Chang, ACK Law - Progress in Neurobiology, 2010 - Elsevier
Alzheimer's disease (AD) is the leading neurodegenerative cause of dementia in the elderly.
Thus far, there is no curative treatment for this devastating condition, thereby creating …

Depression and Alzheimer's disease: neurobiological links and common pharmacological targets

F Caraci, A Copani, F Nicoletti, F Drago - European journal of …, 2010 - Elsevier
Depression is one of the most prevalent and life-threatening forms of mental illnesses,
whereas Alzheimer's disease is a neurodegenerative disorder that affects more than 37 …

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

[HTML][HTML] Pharmacological treatment of depression in Alzheimer's disease: a challenging task

T Cassano, S Calcagnini, A Carbone… - Frontiers in …, 2019 - frontiersin.org
Besides the memory impairment, Alzheimer's disease (AD) is often complicated by
neuropsychiatric symptoms also known as behavioral and psychological symptoms of …

Depressed or demented: common CNS drug targets?

MK Sun, DL Alkon - Current Drug Targets-CNS & Neurological …, 2002 - ingentaconnect.com
A body of evidence emerging in antidepressant and antidementia research has revealed a
convergence of molecular events known to regulate neuronal plasticity in learning and …

Advances in Therapeutics to Alleviate Cognitive Decline and Neuropsychiatric Symptoms of Alzheimer's Disease

J Li, A Haj Ebrahimi, AB Ali - International Journal of Molecular Sciences, 2024 - mdpi.com
Dementia exists as a 'progressive clinical syndrome of deteriorating mental function
significant enough to interfere with activities of daily living', with the most prevalent type of …

Pathogenesis of depression in Alzheimer's disease

Q Zhan, F Kong, S Shao, B Zhang, S Huang - Neurochemical Research, 2024 - Springer
Depression is a prevalent occurrence among Alzheimer's disease (AD) patients, yet its
underlying mechanism remains unclear. Recent investigations have revealed that several …

The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

E Pitsillou, SM Bresnehan, EA Kagarakis… - Molecular biology …, 2020 - Springer
Major depressive disorder (MDD) is considered a serious public health issue that adversely
impacts an individual's quality of life and contributes significantly to the global burden of …

Novel targets for parkinsonism-depression comorbidity

Y Tizabi, B Getachew, AB Csoka, KF Manaye… - Progress in Molecular …, 2019 - Elsevier
With the aging population growing and the incidence of neurodegenerative diseases on the
rise, the researchers in the field are yet more urgently challenged to slow and/or reverse the …