[图书][B] Translational Research Methods for Major Depressive Disorder

YK Kim, M Amidfar - 2022 - Springer
Major depressive disorder (MDD) is a debilitating psychological disorder with a constellation
of heterogeneous symptoms characterized by altered emotional, cognitive, and behavioral …

Mechanisms of antidepressant action: an integrated dopaminergic perspective

S Porcelli, A Drago, C Fabbri, A Serretti - Progress in Neuro …, 2011 - Elsevier
The molecular mechanisms that cause and maintain the major depressive disorder (MDD)
are currently unknown. Consistently, antidepressant treatments are characterized by …

Major depressive disorder: hypothesis, mechanism, prevention and treatment

L Cui, S Li, S Wang, X Wu, Y Liu, W Yu… - … and Targeted Therapy, 2024 - nature.com
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Targeting inflammation: a potential approach for the treatment of depression

S Bhatt, T Devadoss, NK Jha, M Baidya, G Gupta… - Metabolic Brain …, 2023 - Springer
Major depressive disorder (MDD) or Depression is one of the serious neuropsychiatric
disorders affecting over 280 million people worldwide. It is 4th important cause of disability …

Targeting an old mechanism in a new disease—protection of glutamatergic dysfunction in depression

R Sattler, JD Rothstein - Biological psychiatry, 2007 - biologicalpsychiatryjournal.com
Depression is one of the most prevalent psychiatric disor-ders and has been estimated to
affect about 121 million people worldwide. According to the World Health Organization, it is …

Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application

MJ Millan - Pharmacology & therapeutics, 2006 - Elsevier
Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Defeating the Dementors

P Stern - Science, 2012 - science.org
Depression is a devastating disease. It affects not only the directly afflicted but also the
people around them, their families, and their closest relations. It indiscriminately hits all …

The neurobiology of depression: An integrated view

J Dean, M Keshavan - Asian journal of psychiatry, 2017 - Elsevier
Abstract Major Depressive Disorder (MDD) is one of the most common and debilitating
mental disorders; however, its etiology remains unclear. This paper aims to summarize the …

Biomarkers for depression: recent insights, current challenges and future prospects

R Strawbridge, AH Young, AJ Cleare - Focus, 2018 - Am Psychiatric Assoc
A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …

Major depression, cognitive dysfunction and Alzheimer's disease: is there a link?

ASR Sierksma, DLA van den Hove… - European Journal of …, 2010 - Elsevier
Major depression (MD) is a severe mental disorder characterized by alterations in mood and
cognition, with disease severity correlating inversely with cognition scores. Neuropathology …