Current progress in NK cell biology and NK cell-based cancer immunotherapy

R Tarazona, N Lopez-Sejas, B Guerrero… - Cancer Immunology …, 2020 - Springer
A better understanding of the complex interactions between the immune system and tumour
cells from different origins has opened the possibility to design novel procedures of …

[HTML][HTML] Emerging NK cell therapies for cancer and the promise of next generation engineering of iPSC-derived NK cells

S Maddineni, JL Silberstein… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Adoptive cell therapy is a rapidly advancing approach to cancer immunotherapy that seeks
to facilitate antitumor responses by introducing potent effector cells into the tumor …

Tumor-and cytokine-primed human natural killer cells exhibit distinct phenotypic and transcriptional signatures

M Sabry, A Zubiak, SP Hood, P Simmonds… - PLoS …, 2019 - journals.plos.org
An emerging cellular immunotherapy for cancer is based on the cytolytic activity of natural
killer (NK) cells against a wide range of tumors. Although in vitro activation, or “priming,” of …

New views on natural killer cell-based immunotherapy for melanoma treatment

S Burke, T Lakshmikanth, F Colucci, E Carbone - Trends in immunology, 2010 - cell.com
Natural killer (NK) cell-based immunotherapies treat hematopoietic malignancies, but are
less effective against solid tumors. Here, we review recent data on NK cell recognition of …

Challenges to the broad application of allogeneic natural killer cell immunotherapy of cancer

PR Kennedy, M Felices, JS Miller - Stem Cell Research & Therapy, 2022 - Springer
Natural killer (NK) cells are innate immune cells that recognize malignant cells through a
wide array of germline-encoded receptors. Triggering of activating receptors results in …

The changing role of natural killer cells in cancer metastasis

IS Chan, AJ Ewald - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and
antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as …

Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment

UY Moreno-Nieves, JK Tay… - Proceedings of the …, 2021 - National Acad Sciences
Natural killer (NK) cells comprise one subset of the innate lymphoid cell (ILC) family. Despite
reported antitumor functions of NK cells, their tangible contribution to tumor control in …

[HTML][HTML] NK cells and ILCs in tumor immunotherapy

S Sivori, D Pende, L Quatrini, G Pietra… - Molecular aspects of …, 2021 - Elsevier
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …

Tricking the balance: NK cells in anti-cancer immunity

J Pahl, A Cerwenka - Immunobiology, 2017 - Elsevier
Natural Killer (NK) cells are classically considered innate immune effector cells involved in
the first line of defense against infected and malignant cells. More recently, NK cells have …

The role of natural killer cell in gastrointestinal cancer: killer or helper

F Wang, JKC Lau, J Yu - Oncogene, 2021 - nature.com
Gastrointestinal cancer is one of the leading health problems worldwide, with a high
morbidity and mortality. To date, harnessing both the innate and adaptive immune system …