Understanding cardiovascular disease: a journey through the genome (and what we found there)

E Lara-Pezzi, A Dopazo… - Disease models & …, 2012 - journals.biologists.com
Cardiovascular disease (CVD) is a major cause of mortality and hospitalization worldwide.
Several risk factors have been identified that are strongly associated with the development …

Machine learning–based risk assessment for cancer therapy–related cardiac dysfunction in 4300 longitudinal oncology patients

Y Zhou, Y Hou, M Hussain, SA Brown… - Journal of the …, 2020 - Am Heart Assoc
Background The growing awareness of cardiovascular toxicity from cancer therapies has led
to the emerging field of cardio‐oncology, which centers on preventing, detecting, and …

[HTML][HTML] Pathophysiology of cardiovascular diseases: new insights into molecular mechanisms of atherosclerosis, arterial hypertension, and coronary artery disease

W Frąk, A Wojtasińska, W Lisińska, E Młynarska… - Biomedicines, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory
system. Atherosclerosis is its major underlying cause. CVDs are chronic and can remain …

Next-generation, genome sequencing-based biomarkers: concerns and challenges for medical practice

DH Roukos - Biomarkers in medicine, 2010 - Taylor & Francis
In their day-to-day clinical practice, physicians are facing the adverse effects and limited
effectiveness of currently used drugs in the treatment of major diseases. Biomarkers …

Identifying novel biomarkers for cardiovascular disease risk prediction

Y Ge, TJ Wang - Journal of internal medicine, 2012 - Wiley Online Library
The primary prevention of cardiovascular disease relies on the ability to identify at‐risk
individuals long before the development of overt events. In the past decade, research into …

Protein biomarkers of new-onset cardiovascular disease: prospective study from the systems approach to biomarker research in cardiovascular disease initiative

X Yin, S Subramanian, SJ Hwang… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Incorporation of novel plasma protein biomarkers may improve current models
for prediction of atherosclerotic cardiovascular disease (ASCVD) risk. Approach and Results …

Risk of cardiometabolic risk factors in women with and without a history of breast cancer: the pathways heart study

ML Kwan, RK Cheng, C Iribarren… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE The incidence of cardiometabolic risk factors in breast cancer (BC) survivors has
not been well described. Thus, we compared risk of hypertension, diabetes, and …

Molecular pathways for cancer angioprevention

A Albini, DM Noonan, N Ferrari - Clinical Cancer Research, 2007 - AACR
By analogy to the success of cardiovascular medicine in reducing mortality through
preventive measures, cancer chemoprevention has the potential to significantly reduce …

[HTML][HTML] The role of CYP450 drug metabolism in precision cardio-oncology

OA Fatunde, SA Brown - International journal of molecular sciences, 2020 - mdpi.com
As many novel cancer therapies continue to emerge, the field of Cardio-Oncology (or onco-
cardiology) has become crucial to prevent, monitor and treat cancer therapy-related …

[HTML][HTML] Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets

C Swanton, JM Larkin, M Gerlinger, AC Eklund… - Genome medicine, 2010 - Springer
Abstract The European Union multi-disciplinary Personalised RNA interference to Enhance
the Delivery of Individualised Cytotoxic and Targeted therapeutics (PREDICT) consortium …