Solubility and dissolution rate enhancement of ibuprofen by co-milling with polymeric excipients
A Hussain, G Smith, KA Khan, NI Bukhari… - European Journal of …, 2018 - Elsevier
The aim of this study was to enhance the kinetic solubility and dissolution rate of ibuprofen
by co-milling with different excipients and to establish the underlying mechanism (s) for such …
by co-milling with different excipients and to establish the underlying mechanism (s) for such …
Improving the wetting and dissolution of ibuprofen using solventless co-milling
S Varghese, C Ghoroi - International journal of pharmaceutics, 2017 - Elsevier
The wetting and dissolution of a BCS class II drug (Ibuprofen) is enhanced by solventless
solid dispersion technique using co-milling. The co-milling is performed in a planetary ball …
solid dispersion technique using co-milling. The co-milling is performed in a planetary ball …
Effect of co-milling on dissolution rate of poorly soluble drugs
M Slámová, K Prausová, J Epikaridisová… - International Journal of …, 2021 - Elsevier
Co-milling of a drug with a co-former is an efficient technique to improve the solubility of
drugs. Besides the particle size reduction, the co-milling process induces a structural …
drugs. Besides the particle size reduction, the co-milling process induces a structural …
Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems
M Newa, KH Bhandari, JO Kim, JS Im… - Chemical and …, 2008 - jstage.jst.go.jp
To improve its solubility, dissolution, and bioavailability; Ibuprofen–polyethylene glycol 8000
(PEG 8000) solid dispersions (SDs) with different drug loadings were prepared …
(PEG 8000) solid dispersions (SDs) with different drug loadings were prepared …
Physical characterization and dissolution properties of ibuprofen: Eudragit coprecipitates
MS Kislalioglu, MA Khan, C Blount… - Journal of …, 1991 - Wiley Online Library
Ibuprofen: Eudragit coprecipitates were prepared in 10: 3 ratios and their physical properties
and related dissolution characteristics were determined. The Eudragit polymers used for the …
and related dissolution characteristics were determined. The Eudragit polymers used for the …
Analysis of formulation effects in the dissolution of ibuprofen pellets
FO Costa, A Pais, JJS Sousa - International journal of pharmaceutics, 2004 - Elsevier
In this work the effects of citric acid and of two common fillers, lactose (soluble) and
tricalcium phosphate (insoluble) are examined on the release profiles from pellets, using …
tricalcium phosphate (insoluble) are examined on the release profiles from pellets, using …
Preparation and evaluation of fast dissolving ibuprofen-polyethylene glycol 6000 solid dispersions
M Newa, KH Bhandari, JA Kim, BK Yoo, HG Choi… - Drug …, 2008 - Taylor & Francis
To improve its oral absorption, rapidly dissolving ibuprofen solid dispersions (SD) were
prepared in a relatively easy, simple, quick, inexpensive, and reproducible manner …
prepared in a relatively easy, simple, quick, inexpensive, and reproducible manner …
Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders
This study investigates the effects of a variety of coating materials on the flowability and
dissolution of dry-coated cohesive ibuprofen powders, with the ultimate aim to use these in …
dissolution of dry-coated cohesive ibuprofen powders, with the ultimate aim to use these in …
Influence of cellulose ether mixtures on ibuprofen release: MC25, HPC and HPMC K100M
ML Vueba, LAE Batista de Carvalho… - Pharmaceutical …, 2006 - Taylor & Francis
The influence of cellulose ether derivatives on ibuprofen release from matrix tablets was
investigated. Raman spectroscopy and differential scanning calorimetry (DSC) experiments …
investigated. Raman spectroscopy and differential scanning calorimetry (DSC) experiments …
Characterization of ibuproxam binary and ternary dispersions with hydrophilic carriers
This work investigates the possibility of increasing the dissolution properties of ibuproxam (a
poorly water‐soluble anti‐inflammatory drug) using hydrophilic carriers such as …
poorly water‐soluble anti‐inflammatory drug) using hydrophilic carriers such as …