Solubility and dissolution rate enhancement of ibuprofen by co-milling with polymeric excipients

A Hussain, G Smith, KA Khan, NI Bukhari… - European Journal of …, 2018 - Elsevier
The aim of this study was to enhance the kinetic solubility and dissolution rate of ibuprofen
by co-milling with different excipients and to establish the underlying mechanism (s) for such …

Improving the wetting and dissolution of ibuprofen using solventless co-milling

S Varghese, C Ghoroi - International journal of pharmaceutics, 2017 - Elsevier
The wetting and dissolution of a BCS class II drug (Ibuprofen) is enhanced by solventless
solid dispersion technique using co-milling. The co-milling is performed in a planetary ball …

Effect of co-milling on dissolution rate of poorly soluble drugs

M Slámová, K Prausová, J Epikaridisová… - International Journal of …, 2021 - Elsevier
Co-milling of a drug with a co-former is an efficient technique to improve the solubility of
drugs. Besides the particle size reduction, the co-milling process induces a structural …

Enhancement of solubility, dissolution and bioavailability of ibuprofen in solid dispersion systems

M Newa, KH Bhandari, JO Kim, JS Im… - Chemical and …, 2008 - jstage.jst.go.jp
To improve its solubility, dissolution, and bioavailability; Ibuprofen–polyethylene glycol 8000
(PEG 8000) solid dispersions (SDs) with different drug loadings were prepared …

Physical characterization and dissolution properties of ibuprofen: Eudragit coprecipitates

MS Kislalioglu, MA Khan, C Blount… - Journal of …, 1991 - Wiley Online Library
Ibuprofen: Eudragit coprecipitates were prepared in 10: 3 ratios and their physical properties
and related dissolution characteristics were determined. The Eudragit polymers used for the …

Analysis of formulation effects in the dissolution of ibuprofen pellets

FO Costa, A Pais, JJS Sousa - International journal of pharmaceutics, 2004 - Elsevier
In this work the effects of citric acid and of two common fillers, lactose (soluble) and
tricalcium phosphate (insoluble) are examined on the release profiles from pellets, using …

Preparation and evaluation of fast dissolving ibuprofen-polyethylene glycol 6000 solid dispersions

M Newa, KH Bhandari, JA Kim, BK Yoo, HG Choi… - Drug …, 2008 - Taylor & Francis
To improve its oral absorption, rapidly dissolving ibuprofen solid dispersions (SD) were
prepared in a relatively easy, simple, quick, inexpensive, and reproducible manner …

Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders

L Qu, QT Zhou, JA Denman, PJ Stewart… - European Journal of …, 2015 - Elsevier
This study investigates the effects of a variety of coating materials on the flowability and
dissolution of dry-coated cohesive ibuprofen powders, with the ultimate aim to use these in …

Influence of cellulose ether mixtures on ibuprofen release: MC25, HPC and HPMC K100M

ML Vueba, LAE Batista de Carvalho… - Pharmaceutical …, 2006 - Taylor & Francis
The influence of cellulose ether derivatives on ibuprofen release from matrix tablets was
investigated. Raman spectroscopy and differential scanning calorimetry (DSC) experiments …

Characterization of ibuproxam binary and ternary dispersions with hydrophilic carriers

M Cirri, P Mura, AM Rabasco, JM Gines… - Drug development …, 2004 - Taylor & Francis
This work investigates the possibility of increasing the dissolution properties of ibuproxam (a
poorly water‐soluble anti‐inflammatory drug) using hydrophilic carriers such as …