The study of N-linked glycans is among the most challenging bioanalytical tasks because of
their complexity and variety. The presence of glycoform families that differ only in branching …

Sialic acids have diverse biological roles, ranging from promoting up to preventing protein
and cellular recognition in health and disease. The various functions of these …

Sialylated N-glycans play pivotal role in several important biological and pathological
processes. Their sialyl-linkage isomers, mostly α-2, 3-and α-2, 6-linked, act differently during …

A number of alterations to the normal glycomic profile have been previously described for a
number of diseases and disorders, thus underscoring the medical importance of studying …

Changes of α-2, 3-/α-2, 6-linked sialic acids (SAs) in sialylglycans have been found to be
closely related with some diseases. However, accurate quantification of sialylglycans at the …

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been used
for high-throughput glycan profiling analysis. In spite of the biological importance of sialic …

Sialylation can influence the stability, half-life, and immunogenicity of glycoproteins, but
sialylated N-glycans are known to be difficult to analyze. Human alpha1-acid glycoprotein …

Sialylated N-glycan isomers with α-2, 3 and α-2, 6 linkages play crucial and distinctive roles
in diverse physiological and pathological processes. Changes of α-2, 3-linked sialic acids in …

Linkage isomers (α-2, 3-or α-2, 6-linkage) of sialylated N-glycans are involved in the
emergence and progression of some diseases, so they are of great significance for …

Alterations in oligosaccharides and types of sialic acid (SA) attachments have been
associated with different pathological states. Matrix-assisted laser desorption mass …