Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development

SK Samrat, AM Tharappel, Z Li, H Li - Virus research, 2020 - Elsevier
The recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant concern
to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are …

SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies

AM Almehdi, G Khoder, AS Alchakee, AT Alsayyid… - Infection, 2021 - Springer
Purpose COVID-19 pandemic has emerged as a result of infection by the deadly pathogenic
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing enormous threats …

SARS-CoV-2 spike protein: flexibility as a new target for fighting infection

CL Pierri - Signal Transduction and Targeted Therapy, 2020 - nature.com
The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
crucial for the infection because it mediates the virus entry into human host-cells, through …

Severe acute respiratory syndrome‐coronavirus‐2 spike (S) protein based vaccine candidates: State of the art and future prospects

A Arashkia, S Jalilvand, N Mohajel… - Reviews in medical …, 2021 - Wiley Online Library
Summary Coronavirus disease 2019 (Covid‐19) is caused by severe acute respiratory
syndrome‐coronavirus‐2 (SARS‐CoV‐2) which is responsible for a global pandemic that …

SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines

G Salvatori, L Luberto, M Maffei, L Aurisicchio… - Journal of translational …, 2020 - Springer
COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation
has urgently impelled many companies and public research institutes to concentrate their …

The SARS-CoV-2 spike protein: balancing stability and infectivity

I Berger, C Schaffitzel - Cell research, 2020 - nature.com
SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts
to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its …

D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

J Hu, CL He, QZ Gao, GJ Zhang, XX Cao, QX Long… - BioRxiv, 2020 - biorxiv.org
Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein that mediates SARS-CoV-2 …

[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2

MM Hatmal, W Alshaer, MAI Al-Hatamleh, M Hatmal… - Cells, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …

SARS-CoV-2 spike protein elicits cell signaling in human host cells: implications for possible consequences of COVID-19 vaccines

YJ Suzuki, SG Gychka - Vaccines, 2021 - mdpi.com
The world is suffering from the coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses its …

The SARS-CoV-2 spike glycoprotein as a drug and vaccine target: structural insights into its complexes with ACE2 and antibodies

AC Papageorgiou, I Mohsin - Cells, 2020 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of
the Coronavirus disease (COVID-19) pandemic, has so far resulted in more than 1.1 M …