Background: Polyamines and nitric oxide (NO) have been involved in the pathogenesis of
cardiac hypertrophy. NO can regulate cardiac ion channels by direct actions on G-proteins …

Polyamines are thought to play an essential role in cellular hypertrophy and proliferation.
Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in …

Polyamines (putrescine, spermidine and spermine) are essential for cell growth and
differentiation. Nitric oxide exhibits antihypertrophic functions and inhibits cardiac …

Background/Aim: Polyamines (putrescine, spermidine and spermine) play an essential role
in cell growth, differentiation and apoptosis. Hypertrophy is accompanied by an increase in …

Background/Aims: Studies performed in experimental animals have shown that polyamines
contribute to several physiological and pathological processes, including cardiac …

The role that the induction of cardiac ornithine decarboxylase (ODC), a key enzyme in
polyamine biosynthesis, by beta‐adrenergic agents may have in heart hypertrophy is a …

Polyamines (putrescine, spermidine, and spermine) are present in all higher eukaryotic cells
and are essential for cell growth, differentiation and apoptosis. Sharing common precursor …

Angiotensin II (ANG II) has profound effects on the development and progression of
pathological cardiac hypertrophy; however, the intracellular signaling mechanisms are not …

Cardiac muscle hypertrophy is one of the most important compensatory responses of the
heart to multiple stresses that may be placed on it. If the stress is not relieved, sustained …

The purpose of this study was to determine the role of nitric oxide (NO) in the angiotensin II-
induced hypertrophic response in cultured neonatal rat cardiac myocytes. Angiotensin II …