Anxiety comprises a suite of behaviors to deal with potential threat and is often modeled in
approach–avoidance conflict tasks. Collectively, these tests constitute a predominant …

Animal models of human anxiety often invoke a conflict between approach and avoidance
[1, 2]. In these, a key behavioral assay comprises passive avoidance of potential threat and …

Decisions under threat are crucial to survival and require integration of distinct situational
features, such as threat probability and magnitude. Recent evidence from human lesion and …

The hippocampus plays a central role in the approach–avoidance conflict that is central to
the genesis of anxiety. However, its exact functional contribution has yet to be identified. We …

Rodent models of anxiety have implicated the ventral hippocampus in approach–avoidance
conflict processing. Few studies have, however, examined whether the human hippocampus …

Neural oscillations in hippocampus and medial prefrontal cortex (mPFC) are a hallmark of
rodent anxiety models that build on conflict between approach and avoidance. Yet, the …

Background Rodent approach–avoidance conflict tests are common preclinical models of
human anxiety disorder. Their translational validity mainly rests on the observation that …

Animal approach‐avoidance conflict paradigms have been used extensively to
operationalize anxiety, quantify the effects of anxiolytic agents, and probe the neural basis of …

When environmental cues or stimuli that represent both rewarding and aversive outcomes
are presented, complex computations must be made in order to determine whether …

Approach-avoidance conflict is an important psychological concept that has been used
extensively to better understand cognition and emotion. This review focuses on neural …