Normal mitochondrial function is a critical factor in maintaining cellular homeostasis in
various organs of the body. Due to the involvement of mitochondrial dysfunction in many …

In the process of energy production, mitochondrial networks are key elements to allow
metabolism of substrates into ATP. Many pathological conditions have been associated with …

Mitochondrial dysfunction is part of many pathological states in patients, such as sepsis or
stroke. Presently, the monitoring of mitochondrial function in patients is extremely rare, even …

Reduced nicotinamide adenine dinucleotide (NADH) offers one of the main means to
transfer energy from the tricarboxylic acid cycle to the respiratory chain in the mitochondria …

More than 60 years ago, the idea was introduced that NADH autofluorescence could be
used as a marker of cellular redox state and indirectly also of cellular energy metabolism …

The redox states of the NAD and NADP pyridine nucleotide pools play critical roles in
defining the activity of energy producing pathways, in driving oxidative stress and in …

Metabolism and mitochondrial dysfunction are known to be involved in many different
disease states. We have employed two-photon fluorescence imaging of intrinsic …

Mitochondria play a pivotal role in energy metabolism, programmed cell death and oxidative
stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key …

Mitochondrial NADH fluorescence has been a useful tool in evaluating mitochondrial
energetics both in vitro and in vivo. Mitochondrial NADH fluorescence is enhanced several …

Reduced nicotinamide adenine dinucleotide, NADH, is a major electron donor in the
oxidative phosphorylation and glycolytic pathways in cells. As a result, there has been …