An eight-plex immunoassay for Group A streptococcus serology and vaccine development

AL Whitcombe, F Han, SM McAlister… - Journal of …, 2022 - Elsevier
Abstract Group A Streptococcus (GAS) is a major human pathogen responsible for
superficial infections through to life-threatening invasive disease and the autoimmune …

Performance evaluation of three rapid antigen tests for the diagnosis of group A Streptococci

HN Kim, J Kim, WS Jang, J Nam, CS Lim - BMJ open, 2019 - bmjopen.bmj.com
Objective To compare the diagnostic performance of three rapid antigen detection tests
(RADTs) for group A Streptococcus (GAS). Design A hospital-based, cross-sectional …

Performance characteristics and utilization of rapid antigen test, DNA probe, and culture for detection of group A streptococci in an acute care clinic

KC Chapin, P Blake, CD Wilson - Journal of clinical microbiology, 2002 - Am Soc Microbiol
Group A streptococcus (GAS) antigen testing has become a routine point-of-care (POC) test
in acute care settings. Concern about performance parameters (PP) of these tests as well as …

The human immune response to streptococcal extracellular antigens: clinical, diagnostic, and potential pathogenetic implications

DR Johnson, R Kurlan, J Leckman… - Clinical infectious …, 2010 - academic.oup.com
Background. Determination of an immune response to group A Streptococcus (GAS)
antigens, frequently anti–streptolysin O and anti–DNase B, is crucial for documentation of …

The novel group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute …

P Hanson-Manful, AL Whitcombe, PG Young… - Journal of Infection, 2018 - Elsevier
Objectives Streptococcal serology provides evidence of prior Group A Streptococcus (GAS)
exposure, crucial to the diagnosis of acute rheumatic fever (ARF) and post-streptococcal …

Prospective longitudinal analysis of immune responses in pediatric subjects after pharyngeal acquisition of group A streptococci

ND Hysmith, EL Kaplan, PP Cleary… - Journal of the …, 2017 - academic.oup.com
Background. Despite the significant burden of disease associated with infection by group A s
treptococcus (GAS), little is known about the human immune response to GAS antigens after …

Increased Breadth of Group A Streptococcus Antibody Responses in Children With Acute Rheumatic Fever Compared to Precursor Pharyngitis and Skin Infections

AL Whitcombe, R McGregor, J Bennett… - The Journal of …, 2022 - academic.oup.com
Abstract Background Group A Streptococcus (GAS) causes superficial pharyngitis and skin
infections as well as serious autoimmune sequelae such as acute rheumatic fever (ARF) …

A multicomponent vaccine provides Immunity against local and systemic infections by group a Streptococcus across serotypes

S Bi, M Xu, Y Zhou, X Xing, A Shen, B Wang - MBio, 2019 - Am Soc Microbiol
Group A streptococcus (GAS) species are responsible for a broad spectrum of human
diseases, ranging from superficial to invasive infections, and are associated with …

[HTML][HTML] Development and Characterisation of a Four-Plex Assay to Measure Streptococcus pyogenes Antigen-Specific IgG in Human Sera

AJ Keeley, M Carducci, L Massai, M Pizza… - Methods and …, 2022 - mdpi.com
The measurement of antibodies to vaccine antigens is crucial for research towards a safe
and effective vaccine for Streptococcus pyogenes (Strep A). We describe the establishment …

[HTML][HTML] Multicomponent vaccines against group A Streptococcus can effectively target broad disease presentations

HA Shaw, J Ozanne, K Burns, F Mawas - Vaccines, 2021 - mdpi.com
Group A Streptococcus (GAS) is an important global human pathogen, with a wide range of
disease presentations, from mild mucosal infections like pharyngitis to invasive diseases …